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anti-PCDHGC5 antibody :: Rabbit anti-Mouse PCDHGC5 Polyclonal Antibody

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Catalog # MBS9204539
Unit / Price
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  0.08 mL  /  $165 +1 FREE 8GB USB
  0.4 mL  /  $370 +1 FREE 8GB USB
Product Name

PCDHGC5, Polyclonal Antibody

Popular Item
Full Product Name

PCDHGC5 Antibody (Center)

Product Synonym Names
Protocadherin gamma-C5; PCDH-gamma-C5; PCDHGC5
Antibody/Peptide Pairs
PCDHGC5 peptide (MBS9219039) is used for blocking the activity of PCDHGC5 antibody (MBS9204539)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Positions
499-526
OMIM
604968
3D Structure
ModBase 3D Structure for Q9Y5F6
Clonality
Polyclonal
Isotype
Rabbit Ig
Clone Number
RB31976
Host
Rabbit
Species Reactivity
Mouse
Specificity
This PCDHGC5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 499-526 amino acids from the Central region of human PCDHGC5.
Purity/Purification
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Function
Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
Cellular Location
Cell membrane; Single-pass type I membrane protein
Preparation and Storage
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Other Notes
Small volumes of anti-PCDHGC5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-PCDHGC5 antibody
This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes,subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes.
Applications Tested/Suitable for anti-PCDHGC5 antibody
Western Blot (WB), ELISA (EIA), Immunohistochemistry-Paraffin (IHC-P)
Application Notes for anti-PCDHGC5 antibody
WB~~1:1000
IHC-P~~1:10~50

Western Blot (WB) of anti-PCDHGC5 antibody
PCDHGC5 Antibody (Center) western blot analysis in mouse brain tissue lysates (35ug/lane).This demonstrates the PCDHGC5 antibody detected the PCDHGC5 protein (arrow).
anti-PCDHGC5 antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-PCDHGC5 antibody
PCDHGC5 Antibody (Center) immunohistochemistry analysis in formalin fixed and paraffin embedded human stomach tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of PCDHGC5 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
anti-PCDHGC5 antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for PCDHGC5. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI Related Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
protocadherin gamma-C5 isoform 1
NCBI Official Synonym Full Names
protocadherin gamma subfamily C, 5
NCBI Official Symbol
PCDHGC5  [Similar Products]
NCBI Official Synonym Symbols
PCDH-GAMMA-C5
  [Similar Products]
NCBI Protein Information
protocadherin gamma-C5
UniProt Protein Name
Protocadherin gamma-C5
Protein Family
UniProt Gene Name
PCDHGC5  [Similar Products]
UniProt Synonym Gene Names
PCDH-gamma-C5  [Similar Products]
UniProt Entry Name
PCDGM_HUMAN
NCBI Summary for PCDHGC5
This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes. [provided by RefSeq, Jul 2008]
UniProt Comments for PCDHGC5
PCDHGC5: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 5q31

Cellular Component: integral to membrane; plasma membrane

Molecular Function: calcium ion binding

Biological Process: homophilic cell adhesion
Product References and Citations for anti-PCDHGC5 antibody
Wu, Q., et al. Genome Res. 11(3):389-404(2001)
Nollet, F., et al. J. Mol. Biol. 299(3):551-572(2000)
Yagi, T., et al. Genes Dev. 14(10):1169-1180(2000)
Wu, Q., et al. Proc. Natl. Acad. Sci. U.S.A. 97(7):3124-3129(2000)
Wu, Q., et al. Cell 97(6):779-790(1999)

Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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