NP_035439.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
protein S100-A1
NCBI Official Synonym Full Names
S100 calcium binding protein A1
NCBI Protein Information
protein S100-A1
UniProt Protein Name
Protein S100-A1
UniProt Synonym Protein Names
S-100 protein alpha chain; S-100 protein subunit alpha; S100 calcium-binding protein A1
UniProt Comments for S100
S100A1: Weakly binds calcium but binds zinc very tightly- distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Dimer of either two alpha chains, or two beta chains, or one alpha and one beta chain. Interacts with AGER and CAPZA1. Interacts with FKBP4. Interacts with RYR1 and RYR2. Highly prevalent in heart. Also found in lesser quantities in skeletal muscle and brain. Belongs to the S-100 family.
Protein type: Calcium-binding; Endoplasmic reticulum
Chromosomal Location of Human Ortholog: 3 F1|3 39.24 cM
Cellular Component: A band; cytoplasm; I band; M band; neuron projection; nucleus; sarcoplasmic reticulum; Z disc
Molecular Function: ATPase binding; calcium ion binding; calcium-dependent protein binding; identical protein binding; metal ion binding; protein binding; protein homodimerization activity
Biological Process: negative regulation of transcription from RNA polymerase II promoter; regulation of heart contraction
Research Articles on S100
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Diseases associated with anti-S100 antibody
Organs/Tissues associated with anti-S100 antibody
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