Q14973.1
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
Sodium/bile acid cotransporter
NCBI Official Synonym Full Names
solute carrier family 10 member 1
NCBI Official Synonym Symbols
NCBI Protein Information
sodium/bile acid cotransporter
UniProt Protein Name
Sodium/bile acid cotransporter
UniProt Synonym Protein Names
Cell growth-inhibiting gene 29 protein; Na(+)/bile acid cotransporter; Na(+)/taurocholate transport protein; Sodium/taurocholate cotransporting polypeptide; Solute carrier family 10 member 1
UniProt Synonym Gene Names
NCBI Summary for SLC10A1
The protein encoded by this gene belongs to the sodium/bile acid cotransporter family, which are integral membrane glycoproteins that participate in the enterohepatic circulation of bile acids. Two homologous transporters are involved in the reabsorption of bile acids; the ileal sodium/bile acid cotransporter with an apical cell localization that absorbs bile acids from the intestinal lumen, bile duct and kidney, and the liver-specific sodium/bile acid cotransporter, represented by this protein, that is found in the basolateral membranes of hepatocytes. Bile acids are the catabolic product of cholesterol metabolism, hence this protein is important for cholesterol homeostasis. [provided by RefSeq, Oct 2011]
UniProt Comments for SLC10A1
NTCP: The hepatic sodium/bile acid uptake system exhibits broad substrate specificity and transports various non-bile acid organic compounds as well. It is strictly dependent on the extracellular presence of sodium. Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter
Chromosomal Location of Human Ortholog: 14q24.1
Cellular Component: integral to plasma membrane; plasma membrane
Molecular Function: bile acid:sodium symporter activity
Biological Process: bile acid and bile salt transport; transport
Research Articles on SLC10A1
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Products associated with anti-SLC10A1 antibody
Pathways associated with anti-SLC10A1 antibody
Diseases associated with anti-SLC10A1 antibody
Organs/Tissues associated with anti-SLC10A1 antibody
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