EAW91749.1
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
16,267 Da
NCBI Official Full Name
ubiquinol-cytochrome c reductase binding protein
NCBI Official Synonym Full Names
ubiquinol-cytochrome c reductase binding protein
NCBI Official Synonym Symbols
QPC; QCR7; QP-C; UQBC; UQBP; UQPC; UQCR6; MC3DN3 [Similar Products]
NCBI Protein Information
cytochrome b-c1 complex subunit 7
UniProt Protein Name
Cytochrome b-c1 complex subunit 7
UniProt Synonym Protein Names
Complex III subunit 7; Complex III subunit VII; QP-C; Ubiquinol-cytochrome c reductase complex 14 kDa protein
UniProt Synonym Gene Names
NCBI Summary for UQCRB
This gene encodes a subunit of the ubiquinol-cytochrome c oxidoreductase complex, which consists of one mitochondrial-encoded and 10 nuclear-encoded subunits. The protein encoded by this gene binds ubiquinone and participates in the transfer of electrons when ubiquinone is bound. This protein plays an important role in hypoxia-induced angiogenesis through mitochondrial reactive oxygen species-mediated signaling. Mutations in this gene are associated with mitochondrial complex III deficiency. Alternatively spliced transcript variants have been found for this gene. Related pseudogenes have been identified on chromosomes 1, 5 and X. [provided by RefSeq, Dec 2011]
UniProt Comments for UQCRB
UQCRB: This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This component is involved in redox-linked proton pumping. Defects in UQCRB are a cause of mitochondrial complex III deficiency (MT-C3D). A disorder of the mitochondrial respiratory chain resulting in a highly variable phenotype depending on which tissues are affected. Clinical features include mitochondrial encephalopathy, psychomotor retardation, ataxia, severe failure to thrive, liver dysfunction, renal tubulopathy, muscle weakness and exercise intolerance. Belongs to the UQCRB/QCR7 family.
Protein type: EC 1.10.2.2; Energy Metabolism - oxidative phosphorylation; Mitochondrial; Oxidoreductase
Chromosomal Location of Human Ortholog: 8q22.1
Cellular Component: mitochondrial inner membrane; mitochondrial respiratory chain; mitochondrial respiratory chain complex III
Molecular Function: protein binding; ubiquinol-cytochrome-c reductase activity
Biological Process: aerobic respiration; mitochondrial electron transport, ubiquinol to cytochrome c; oxidative phosphorylation
Disease: Mitochondrial Complex Iii Deficiency, Nuclear Type 3
Research Articles on UQCRB
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Products associated with anti-UQCRB antibody
Pathways associated with anti-UQCRB antibody
Diseases associated with anti-UQCRB antibody
Organs/Tissues associated with anti-UQCRB antibody
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