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anti-ALDH3A2 antibody :: Goat ALDH3A2 Polyclonal Antibody

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Catalog # MBS422399
Unit / Price
  0.1 mg  /  $300 +1 FREE 8GB USB
Western Blot (WB)
Product Name

ALDH3A2, Polyclonal Antibody

Also Known As

Goat anti-ALDH3A2 Antibody

Product Synonym Names
Aldh3a2; aldehyde dehydrogenase 3 family, member A2; Aldh4; FALDH; alcohol dehydrogenase family 3, subfamily A2; aldehyde dehydrogenase 3A2; aldehyde dehydrogenase 4; aldehyde dehydrogenase family 3 member A2; aldehyde dehydrogenase family 3, subfamily A2; alcohol dehydrogenase family 3; subfamily A2 antibody; aldehyde dehydrogenase 3 family; member A2 antibody; aldehyde dehydrogenase 3A2 antibody; aldehyde dehydrogenase 4 antibody; aldehyde dehydrogenase family 3 member A2 antibody; aldehyde dehydrogenase family 3; subfamily A2 antibody; Aldh4 antibody; FALDH antibody; Aldh3a2 antibody
Antibody/Peptide Pairs
ALDH3A2 peptide (MBS427359) is used for blocking the activity of ALDH3A2 antibody (MBS422399)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
484
Immunogen Sequence
KGLKGESVNK LRY
Clonality
Polyclonal
Host
Goat
Species Reactivity
Tested: Mouse, Rat; Expected from sequence similarity: Mouse, Rat
Purity/Purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Form/Format
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Concentration
100ug specific antibody in 200ul (lot specific)
Immunogen
Peptide with sequence C-KGLKGESVNKLRY, from the internal region of the protein sequence according to NP_113919.2.
Epitope
Internal region
Note
This antibody is expected to recognize both reported isoforms (NP_001026976.1; NP_000373.1).
Preparation and Storage
Aliquot and store at -20 degree C. Minimize freezing and thawing.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of anti-ALDH3A2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-ALDH3A2 antibody
Peptide ELISA (EIA), Western Blot (WB)
Application Notes for anti-ALDH3A2 antibody
Peptide ELISA: Antibody detection limit dilution 1: 32000.
Western Blot: Approx 55kDa band observed in Mouse and Rat Liver lysates (calculated MW of 54. 0kDa according to Mouse NP_031463.2 and 54.1kDa according to Rat NP_113919.2). Recommended concentration: 0. 03-0.1ug/ml.

Western Blot (WB) of anti-ALDH3A2 antibody
(0. 03ug/ml) staining of Rat Liver lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
anti-ALDH3A2 antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for ALDH3A2. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Related Accession #
Molecular Weight
54,082 Da
NCBI Official Full Name
fatty aldehyde dehydrogenase
NCBI Official Synonym Full Names
aldehyde dehydrogenase 3 family, member A2
NCBI Official Symbol
Aldh3a2  [Similar Products]
NCBI Official Synonym Symbols
Aldh4; FALDH
  [Similar Products]
NCBI Protein Information
fatty aldehyde dehydrogenase
UniProt Protein Name
Fatty aldehyde dehydrogenase
UniProt Synonym Protein Names
Aldehyde dehydrogenase 4; Aldehyde dehydrogenase family 3 member A2; Microsomal aldehyde dehydrogenase; msALDH
UniProt Gene Name
Aldh3a2  [Similar Products]
UniProt Synonym Gene Names
Aldh4; msALDH  [Similar Products]
UniProt Entry Name
AL3A2_RAT
UniProt Comments for ALDH3A2
ALDH3A2: Catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acids. Active on a variety of saturated and unsaturated aliphatic aldehydes between 6 and 24 carbons in length. Responsible for conversion of the sphingosine 1-phosphate (S1P) degradation product hexadecenal to hexadecenoic acid. Defects in ALDH3A2 are the cause of Sjoegren-Larsson syndrome (SLS). SLS is an autosomal recessive neurocutaneous disorder characterized by a combination of severe mental retardation, spastic di- or tetraplegia and congenital ichthyosis (increased keratinization). Ichthyosis is usually evident at birth, neurologic symptoms appear in the first or second year of life. Most patients have an IQ of less than 60. Additional clinical features include glistening white spots on the retina, seizures, short stature and speech defects. Belongs to the aldehyde dehydrogenase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Oxidoreductase; Mitochondrial; Endoplasmic reticulum; Carbohydrate Metabolism - ascorbate and aldarate; Amino Acid Metabolism - lysine degradation; Carbohydrate Metabolism - butanoate; Lipid Metabolism - glycerolipid; Secondary Metabolites Metabolism - limonene and pinene degradation; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Lipid Metabolism - fatty acid; Amino Acid Metabolism - histidine; Amino Acid Metabolism - arginine and proline; Carbohydrate Metabolism - propanoate; Carbohydrate Metabolism - pyruvate; EC 1.2.1.3; Other Amino Acids Metabolism - beta-alanine; Amino Acid Metabolism - valine, leucine and isoleucine degradation; Amino Acid Metabolism - tryptophan

Cellular Component: cytosol; endoplasmic reticulum; integral to membrane; intracellular membrane-bound organelle; mitochondrial inner membrane; mitochondrion; nucleus; peroxisome

Molecular Function: 3-chloroallyl aldehyde dehydrogenase activity; aldehyde dehydrogenase (NAD) activity; aldehyde dehydrogenase [NAD(P)+] activity; long-chain-alcohol oxidase activity; long-chain-aldehyde dehydrogenase activity

Biological Process: aldehyde metabolic process; central nervous system development; epidermis development; formaldehyde metabolic process; peripheral nervous system development; phytol metabolic process; response to reactive oxygen species; sesquiterpenoid metabolic process
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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