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anti-BDNF antibody :: Rabbit anti-Mouse, Rat Brain Derived Neurotrophic Factor, pro Polyclonal Antibody

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Catalog # MBS629971
Unit / Price
  0.1 mL  /  $610 +1 FREE 8GB USB
anti-BDNF antibody
Product Name

Brain Derived Neurotrophic Factor, pro (BDNF), Polyclonal Antibody

Popular Item
Also Known As

Brain Derived Neurotrophic Factor, pro (proBDNF)

Product Synonym Names
Anti -Brain Derived Neurotrophic Factor, pro (proBDNF)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
MBS629971 Technical Datasheet
Chromosome Location
Chromosome: 11; NC_000011.9 (27676440..27743605, complement). Location: 11p13
OMIM
113505
3D Structure
ModBase 3D Structure for P23560
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Mouse, Rat
Specificity
Recognizes human proBDNF. No cross-reactivity with other pro-neutrotropins was detected.
Purity/Purification
Serum
Form/Format
Supplied as a lyophilized powder. Reconstitute with 100ul of sterile ddH2O.
Grade
Serum
Immunogen
Synthetic peptide corresponding to aa69-82 of human proBDNF, C-ELLDEDQKVRPNEE (KLH).
Preparation and Storage
Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Other Notes
Small volumes of anti-BDNF antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-BDNF antibody
BDNF belongs to the neurotrophin family and regulates the survival and differentiation of neurons during development. The alterations in BDNF expression induced by various kinds of brain insult including stress, ischemia, seizure activity and hypoglycemia, may contribute to some pathologies such as depression, epilepsy, Alzheimer?s, and Parkinson?s disease. Promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability. SUBUNIT: Monomers and homodimers. Binds to NTRK2/TRKB.
Applications Tested/Suitable for anti-BDNF antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-BDNF antibody
Dilution: Immunohistochemistry: 1:1000-1:5000

Western Blot: 1:1000-1:5000. Detects a band at 35kD.

Optimal dilutions to be determined by the researcher.
NCBI/Uniprot data below describe general gene information for BDNF. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
27,818 Da[Similar Products]
NCBI Official Full Name
brain-derived neurotrophic factor
NCBI Official Synonym Full Names
brain-derived neurotrophic factor
NCBI Official Symbol
NCBI Official Synonym Symbols
MGC34632
  [Similar Products]
NCBI Protein Information
brain-derived neurotrophic factor; abrineurin; neurotrophin; OTTHUMP00000232005; OTTHUMP00000232006; OTTHUMP00000232013; OTTHUMP00000232014; OTTHUMP00000232015; OTTHUMP00000232016; OTTHUMP00000232018; OTTHUMP00000232019; OTTHUMP00000232020; OTTHUMP00000232021; OTTHUMP00000232022; OTTHUMP00000232039; OTTHUMP00000232040; OTTHUMP00000232041; OTTHUMP00000232043
UniProt Protein Name
Brain-derived neurotrophic factor
UniProt Synonym Protein Names
Abrineurin
UniProt Gene Name
UniProt Entry Name
BDNF_HUMAN
NCBI Summary for BDNF
The protein encoded by this gene is a member of the nerve growth factor family. It is induced by cortical neurons, and is necessary for survival of striatal neurons in the brain. Expression of this gene is reduced in both Alzheimer's and Huntington disease patients. This gene may play a role in the regulation of stress response and in the biology of mood disorders. Multiple transcript variants encoding distinct isoforms have been described for this gene. [provided by RefSeq]
UniProt Comments for BDNF
BDNF: During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability. Defects in BDNF are a cause of congenital central hypoventilation syndrome (CCHS); also known as congenital failure of autonomic control or Ondine curse. CCHS is a rare disorder characterized by abnormal control of respiration in the absence of neuromuscular or lung disease, or an identifiable brain stem lesion. A deficiency in autonomic control of respiration results in inadequate or negligible ventilatory and arousal responses to hypercapnia and hypoxemia. CCHS is frequently complicated with neurocristopathies such as Hirschsprung disease that occurs in about 16% of CCHS cases. Belongs to the NGF-beta family. 5 isoforms of the human protein are produced by alternative promoter.

Protein type: Secreted, signal peptide; Cytokine; Secreted; Cell development/differentiation

Chromosomal Location of Human Ortholog: 11p13

Cellular Component: extracellular space; mitochondrial crista; synaptic vesicle; perinuclear region of cytoplasm; cytoplasmic membrane-bound vesicle; cytoplasm; dendrite; extracellular region; terminal button; perikaryon

Molecular Function: growth factor activity; neurotrophin TRKB receptor binding

Biological Process: circadian rhythm; axon guidance; mechanoreceptor differentiation; behavioral fear response; mitochondrial electron transport, NADH to ubiquinone; regulation of neuron differentiation; axon extension; response to hormone stimulus; positive regulation of long-term neuronal synaptic plasticity; response to vitamin A; negative regulation of neuroblast proliferation; ureteric bud development; dendrite development; regulation of retinal cell programmed cell death; feeding behavior; negative regulation of neuron apoptosis; negative regulation of synaptic transmission, GABAergic; response to electrical stimulus; inner ear development; response to food; nervous system development; chronic inflammatory response; response to light intensity; neuron recognition; regulation of axon extension; learning; regulation of short-term neuronal synaptic plasticity; negative regulation of striated muscle development; positive regulation of peptidyl-serine phosphorylation; positive regulation of synaptogenesis; response to hyperoxia; axon target recognition; glutamate secretion; response to hypoxia; response to fluoxetine; nerve development; response to activity; regulation of excitatory postsynaptic membrane potential; positive regulation of neuron differentiation; neurite morphogenesis; transmembrane receptor protein tyrosine kinase signaling pathway; gamma-aminobutyric acid signaling pathway

Disease: Bulimia Nervosa, Susceptibility To, 1; Obsessive-compulsive Disorder; Bulimia Nervosa, Susceptibility To, 2; Central Hypoventilation Syndrome, Congenital
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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