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anti-Mb21d1 antibody :: Rabbit anti-Mouse, Rat C6orf150 Polyclonal Antibody

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Catalog # MBS540138
Unit / Price
  0.1 mg Affinity-Purified  /  $425 +1 FREE 8GB USB
Immunohistochemistry (IHC)
Product Name

C6orf150 (Mb21d1), Polyclonal Antibody

Popular Item
Also Known As

C6orf150 Antibody

Product Synonym Names
C6orf150; cGAMP synthase; cGAS; Chromosome 6 open reading frame 150; Cyclic GMP-AMP synthase; h-cGAS; Hypothetical protein LOC115004; Mab 21 domain containing 1; MB21D1; protein MB21D1; Uncharacterized protein C6orf150 antibody
Matching Pairs
Antibody: C6orf150 (MBS540138)
Positive Control: C6orf150 (MBS542627)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
507
3D Structure
ModBase 3D Structure for Q8C6L5
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Mouse, Rat
Form/Format
Affinity Purified
Concentration
0.60 ug/ul in antibody stabilization buffer (lot specific)
Immunogen
Synthetic peptide taken within amino acid region 450-500 on mouse cGAS protein.
Expression
Is expressed in the monocytic cell line THP1 by type 1 Interferons
Molecular Function
Nucleotidyltransferase; ATP binding; DNA binding
Structure
Monomer when in absence of DNA. Homodimer when bound to DNA.
Subcellular Location
Cytoplasm; Cytosol
Preparation and Storage
-20 degree C for long term storage
Other Notes
Small volumes of anti-Mb21d1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-Mb21d1 antibody
Affinity Purified Cyclic GMP-AMP synthase Antibody
Catalyzes the formation of cyclic GMP-AMP from ATP and GTP. Has antiviral activity through acting as a cystolic DNA senser.
Applications Tested/Suitable for anti-Mb21d1 antibody
ELISA (EIA), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB)
Application Notes for anti-Mb21d1 antibody
Dot Blot: 1:10,000
ELISA: 1:10,000
Immunoprecipitation: 1:150
Western Blot: 1:500

Immunohistochemistry (IHC) of anti-Mb21d1 antibody
anti-Mb21d1 antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for Mb21d1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
58,194 Da[Similar Products]
NCBI Official Full Name
cyclic GMP-AMP synthase
NCBI Official Synonym Full Names
Mab-21 domain containing 1
NCBI Official Symbol
Mb21d1  [Similar Products]
NCBI Official Synonym Symbols
cGAS; E330016A19Rik
  [Similar Products]
NCBI Protein Information
cyclic GMP-AMP synthase
UniProt Protein Name
Cyclic GMP-AMP synthase
UniProt Synonym Protein Names
2'3'-cGAMP synthase; Mab-21 domain-containing protein 1
Protein Family
UniProt Gene Name
Mb21d1  [Similar Products]
UniProt Synonym Gene Names
cGAMP synthase; cGAS; m-cGAS  [Similar Products]
UniProt Entry Name
CGAS_MOUSE
NCBI Summary for Mb21d1
The protein encoded by this gene is a DNA binding cytosolic protein that catalyzes the synthesis of cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) after sensing the presence of DNA in the cytoplasm. cGAMP binds another protein, Stimulator of interferon genes (STING), leading to the induction of interferons, and a host immune response. Reduced expression of this gene inhibits interferon induction in the presence of some viral infections. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
UniProt Comments for Mb21d1
MB21D1: Nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (cGAMP) from ATP and GTP. Catalysis involves both the formation of a 2',5' phosphodiester linkage at the GpA step and the formation of a 3',5' phosphodiester linkage at the ApG step, producing c[G(2',5')pA(3',5')p]. Has antiviral activity by acting as a key cytosolic DNA sensor, the presence of double-stranded DNA (dsDNA) in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production.

Protein type: Enzyme, cellular metabolism; EC 2.7.7.86

Cellular Component: cytoplasm; cytosol

Molecular Function: ATP binding; DNA binding; GTP binding; metal ion binding; nucleotide binding; nucleotidyltransferase activity; transferase activity

Biological Process: activation of innate immune response; cyclic nucleotide biosynthetic process; defense response to virus; immune system process; innate immune response; positive regulation of defense response to virus by host
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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