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anti-CACNA2D2 antibody :: Rabbit anti-Mouse, Rat CACNA2D2 Polyclonal Antibody

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Catalog # MBS9130778 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
Unit / Price
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  0.05 mL  /  $200 +1 FREE 8GB USB
  0.1 mL  /  $275 +1 FREE 8GB USB
  0.2 mL  /  $430 +1 FREE 8GB USB
Western Blot (WB)
Product Name

CACNA2D2, Polyclonal Antibody

Popular Item
Full Product Name

CACNA2D2 Polyclonal Antibody

Product Synonym Names
CACNA2D
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
AF042792 mRNA
3D Structure
ModBase 3D Structure for Q9NY47
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Mouse, Rat
Purity/Purification
Affinity Purification
Immunogen
Recombinant protein of human CACNA2D2
Storage Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Preparation and Storage
Store at -20 degree C. Avoid freeze/thaw cycles.
Other Notes
Small volumes of anti-CACNA2D2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-CACNA2D2 antibody
Calcium channels mediate the entry of calcium ions into the cell upon membrane polarization. This gene encodes the alpha-2/delta subunit of the voltage-dependent calcium channel complex. The complex consists of the main channel-forming subunit alpha-1, and auxiliary subunits alpha-2/delta, beta, and gamma. The auxiliary subunits function in the assembly and membrane localization of the complex, and modulate calcium currents and channel activation/inactivation kinetics. The subunit encoded by this gene undergoes post-translational cleavage to yield the extracellular alpha2 peptide and a membrane-anchored delta polypeptide. This subunit is a receptor for the antiepileptic drug, gabapentin. Mutations in this gene are associated with early infantile epileptic encephalopathy. Single nucleotide polymorphisms in this gene are correlated with increased sensitivity to opioid drugs. Alternative splicing results in multiple transcript variants encoding different isoforms.
Product Categories/Family for anti-CACNA2D2 antibody
Applications Tested/Suitable for anti-CACNA2D2 antibody
Western Blot (WB)
Application Notes for anti-CACNA2D2 antibody
WB: 1:200 - 1:2000

Western Blot (WB) of anti-CACNA2D2 antibody
Western blot analysis of extracts of various cell lines, using CACNA2D2 antibody at 1:1000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Enhanced Kit.
Exposure time: 1s.
anti-CACNA2D2 antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for CACNA2D2. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
130kDa
NCBI Official Full Name
Voltage-dependent calcium channel subunit alpha-2/delta-2
NCBI Official Synonym Full Names
calcium voltage-gated channel auxiliary subunit alpha2delta 2
NCBI Official Symbol
CACNA2D2  [Similar Products]
NCBI Official Synonym Symbols
CACNA2D
  [Similar Products]
NCBI Protein Information
voltage-dependent calcium channel subunit alpha-2/delta-2
UniProt Protein Name
Voltage-dependent calcium channel subunit alpha-2/delta-2
UniProt Synonym Protein Names
Voltage-gated calcium channel subunit alpha-2/delta-2
UniProt Gene Name
CACNA2D2  [Similar Products]
UniProt Synonym Gene Names
KIAA0558  [Similar Products]
NCBI Summary for CACNA2D2
Calcium channels mediate the entry of calcium ions into the cell upon membrane polarization. This gene encodes the alpha-2/delta subunit of the voltage-dependent calcium channel complex. The complex consists of the main channel-forming subunit alpha-1, and auxiliary subunits alpha-2/delta, beta, and gamma. The auxiliary subunits function in the assembly and membrane localization of the complex, and modulate calcium currents and channel activation/inactivation kinetics. The subunit encoded by this gene undergoes post-translational cleavage to yield the extracellular alpha2 peptide and a membrane-anchored delta polypeptide. This subunit is a receptor for the antiepileptic drug, gabapentin. Mutations in this gene are associated with early infantile epileptic encephalopathy. Single nucleotide polymorphisms in this gene are correlated with increased sensitivity to opioid drugs. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2014]
UniProt Comments for CACNA2D2
CACNA2D2: The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q-type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) and possibly T-type (CACNA1G). Overexpression induces apoptosis. Belongs to the calcium channel subunit alpha-2/delta family. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 3p21.31

Cellular Component: plasma membrane

Molecular Function: voltage-gated calcium channel activity

Biological Process: regulation of insulin secretion
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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