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anti-GM-CSF antibody :: Rabbit anti-Mouse, Rat GM-CSF Polyclonal Antibody

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Catalog # MBS551019
Unit / Price
  0.1 mg  /  $280 +1 FREE 8GB USB
  0.2 mg  /  $385 +1 FREE 8GB USB
anti-GM-CSF antibody
Product Name

GM-CSF, Polyclonal Antibody

Popular Item
Also Known As

Rabbit anti GM-CSF Polyclonal

Product Synonym Names
Rabbit anti GM-CSF Polyclonal purified; GM-CSF; gmcsf; csf2; Granulocyte Macrophage-Colony Stimulating Factor; polyclonal; pab
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
144
OMIM
138960
3D Structure
ModBase 3D Structure for P04141
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Mouse, Rat
Purity/Purification
Purification: IgG fraction was purified by Protein G affinity chromatography.
Purity: >95%
Form/Format
Lyophilized from sterile filtered PBS solution at a concentration of 1mg/ml.
Source Note
Polyclonal GM-CSF antibody was produced from sera of rabbits immunized with synthetic protein containing GM-CSF antigenic determinants.
Reconstitution
A quick spin of the vial followed by reconstitution in distilled water. This solution can then be diluted into other buffers
Presentation
Lyophilized from 0.2 um filtered solution in PBS pH 7.4.
Reconsitution
Add 100ul of distilled H20 for a concentration of 1mg/ml.
Preparation and Storage
The lyophilized antibody is stable for at least 1 year from date of receipt at -20degree C. Upon reconstitution, this antibody can be stored in working aliquots at 20 - 80 degree C for one month, or at -20 degree C for six months without detectable loss of activity.
Avoid repeated freeze/thaw cycles.
Other Notes
Small volumes of anti-GM-CSF antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-GM-CSF antibody
GM-CSF is a monomeric protein of 127 amino acids with two glycosylation sites. The protein is synthesized as a precursor of 144 amino acids, which included a hydrophobic secretory signal sequence at the aminoterminal end. The sugar moiety is not required for the full spectrum of biological activities. Non- glycosylated and glycosylated GM-CSF show the same activities in vitro. Fully glycosylated GM-CSF is biologically more active in vivo than the non- glycosylated protein. This protein is secreted together with other factors by T- cells and macrophages following cell activation by antigens or mitogens. Approximately 90% of the secreted colony stimulating activities are due to GM- CSF.
Product Categories/Family for anti-GM-CSF antibody
Applications Tested/Suitable for anti-GM-CSF antibody
Western Blot (WB), IHC (Immunohistochemistry), ELISA (EIA)
Application Notes for anti-GM-CSF antibody
ELISA: Use at a concentration range of 1-2ug/ml.
Western blot: A suitable range of concentrations of this antibody for WB detection is 2-10 ug/ml.
IHC: A suitable range of concentrations of this antibody for IHC is 2-10 ug/ml.
NCBI/Uniprot data below describe general gene information for GM-CSF. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
granulocyte-macrophage colony-stimulating factor
UniProt Protein Name
Granulocyte-macrophage colony-stimulating factor
UniProt Synonym Protein Names
Colony-stimulating factor; CSF; Molgramostin; Sargramostim
UniProt Gene Name
UniProt Synonym Gene Names
GMCSF; GM-CSF; CSF  [Similar Products]
UniProt Entry Name
CSF2_HUMAN
NCBI Summary for GM-CSF
The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of granulocytes and macrophages. The active form of the protein is found extracellularly as a homodimer. This gene has been localized to a cluster of related genes at chromosome region 5q31, which is known to be associated with interstitial deletions in the 5q- syndrome and acute myelogenous leukemia. Other genes in the cluster include those encoding interleukins 4, 5, and 13. [provided by RefSeq, Jul 2008]
UniProt Comments for GM-CSF
GMCSF: Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. Belongs to the GM-CSF family.

Protein type: Secreted; Cytokine; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 5q31.1

Cellular Component: extracellular space; extracellular region

Molecular Function: protein binding; growth factor activity; granulocyte macrophage colony-stimulating factor receptor binding; cytokine activity

Biological Process: negative regulation of cytolysis; epithelial fluid transport; macrophage activation; embryonic placenta development; positive regulation of tyrosine phosphorylation of Stat5 protein; positive regulation of interleukin-23 production; positive regulation of cell proliferation; myeloid dendritic cell differentiation; immune response; positive regulation of DNA replication

Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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Organs/Tissues associated with anti-GM-CSF antibody
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