NP_036714.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
haptoglobin
NCBI Official Synonym Full Names
haptoglobin
NCBI Official Synonym Symbols
NCBI Protein Information
haptoglobin
UniProt Protein Name
Haptoglobin
UniProt Synonym Protein Names
Liver regeneration-related protein LRRG173; Zonulin
UniProt Entry Name
HPT_RAT
NCBI Summary for Hp
may bind hemoglobin and mediate hemoglobin catabolism in lung cells; may play a role in inflammatory response [RGD, Feb 2006]
UniProt Comments for Hp
HP: Haptoglobin combines with free plasma hemoglobin, preventing loss of iron through the kidneys and protecting the kidneys from damage by hemoglobin, while making the hemoglobin accessible to degradative enzymes. Defects in HP are the cause of anhaptoglobinemia (AHP). AHP is a condition characterized by the absence of the serum glycoprotein haptoglobin. Serum levels of haptoglobin vary among normal persons: levels are low in the neonatal period and in the elderly, differ by population, and can be influenced by environmental factors, such as infection. Secondary hypohaptoglobinemia can occur as a consequence of hemolysis, during which haptoglobin binds to free hemoglobin. Belongs to the peptidase S1 family.
Protein type: Protease; Enzyme, misc.; Endoplasmic reticulum; Secreted, signal peptide; Secreted
Cellular Component: endoplasmic reticulum; extracellular region; extracellular space; Golgi apparatus
Molecular Function: antioxidant activity; hemoglobin binding; protein homodimerization activity; serine-type endopeptidase activity
Biological Process: acute inflammatory response; acute-phase response; defense response to bacterium; immune system process; liver development; negative regulation of oxidoreductase activity; Notch signaling pathway; organ regeneration; proteolysis; response to cobalamin; response to drug; response to electrical stimulus; response to glucocorticoid stimulus; response to heat; response to hydrogen peroxide; response to hypoxia; response to L-ascorbic acid; response to lead ion; response to lipopolysaccharide; response to magnesium ion; response to organic cyclic substance; response to organic substance; response to X-ray; spermatogenesis
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Pathways associated with anti-Hp antibody
Diseases associated with anti-Hp antibody
Organs/Tissues associated with anti-Hp antibody
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