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anti-KIRREL antibody :: Rabbit anti-Mouse, Rat KIRREL Polyclonal Antibody

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Catalog # MBS542190
Unit / Price
  0.1 mg Affinity-Purified  /  $425 +1 FREE 8GB USB
anti-KIRREL antibody
Product Name

KIRREL, Polyclonal Antibody

Popular Item
Also Known As

Rabbit Polyclonal KIRREL Antibody

Product Synonym Names
FLJ10845; Kin of IRRE like (Drosophila); Kin of IRRE like; Kin of irregular chiasm-like protein 1; Kirrel; MGC129542; MGC129543; NEPH 1; Nephrin like protein 1; Nephrin related antibody
Matching Pairs
Antibody: KIRREL (MBS542190)
Positive Control: KIRREL (MBS542983)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
789
3D Structure
ModBase 3D Structure for Q80W68
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Mouse, Rat
Form/Format
Affinity Purified Immunoglobulins
Concentration
0.65 mg/ml IgG in antibody stabilization buffer (lot specific)
Immunogen
Recombinant protein
Expression
Abundantly expressed in kidney. Specifically expressed in podocytes of kidney glomeruli.
Molecular Function
Myosin Binding
Structure
Interacts with TJP1/ZO-1 and with NPHS2/podocin (via the C-terminus). Interacts with NPHS1/nephrin (via the Ig-like domains); this interaction is dependent on KIRREL glycosylation. Homodimer (via the Ig-like domains). Interacts when tyrosine-phosphorylated with GRB2.
Subcellular Location
Cell membrane; Single-pass type I membrane protein
Preparation and Storage
-20 degree C for long term storage
Other Notes
Small volumes of anti-KIRREL antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-KIRREL antibody
Affinity Purified Kin of IRRE-like protein 1 Antibody
Plays a significant role in the normal development and function of the glomerular permeability. Is a signaling protein that needs the presence of TEC kinases to fully trans-activate the transcription factor AP-1.
Applications Tested/Suitable for anti-KIRREL antibody
Confocal Microscopy (CM), ELISA (EIA), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB)
Application Notes for anti-KIRREL antibody
Confocal Microscopy||1:250
Dot Blot: 1:10,000
ELISA: 1:10,000
Immunocytochemistry: 1:250
Immunofluorescence: 1:250
Immunohistochemistry: 1:250
Immunoprecipitation: 1:250
Western Blot: 1:250
NCBI/Uniprot data below describe general gene information for KIRREL. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
69,967 Da
NCBI Official Full Name
Kin of IRRE-like protein 1
NCBI Official Synonym Full Names
kin of IRRE like (Drosophila)
NCBI Official Symbol
Kirrel  [Similar Products]
NCBI Official Synonym Symbols
Neph1; Kirrel1; 6720469N11Rik
  [Similar Products]
NCBI Protein Information
kin of IRRE-like protein 1
UniProt Protein Name
Kin of IRRE-like protein 1
UniProt Synonym Protein Names
Kin of irregular chiasm-like protein 1; Nephrin-like protein 1
Protein Family
UniProt Gene Name
Kirrel  [Similar Products]
UniProt Synonym Gene Names
Kirrel1; Neph1  [Similar Products]
UniProt Entry Name
KIRR1_MOUSE
UniProt Comments for KIRREL
KIRREL: Plays a significant role in the normal development and function of the glomerular permeability. Signaling protein that needs the presence of TEC kinases to fully trans-activate the transcription factor AP-1. Belongs to the immunoglobulin superfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Cell adhesion

Cellular Component: cell projection membrane; dendritic shaft; integral to membrane; intercellular junction; lipid raft; membrane; perinuclear region of cytoplasm; plasma membrane

Molecular Function: myosin binding; protein binding

Biological Process: cell-cell adhesion; excretion; negative regulation of protein amino acid phosphorylation; positive regulation of actin filament polymerization
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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