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anti-STRA6 antibody :: Goat STRA6 Polyclonal Antibody

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Catalog # MBS421539
Unit / Price
  0.1 mg  /  $300 +1 FREE 8GB USB
Western Blot (WB)
Product Name

STRA6, Polyclonal Antibody

Full Product Name

Goat anti-STRA6 (mouse, rat) Antibody

Product Synonym Names
STRA6; stimulated by retinoic acid gene 6 homolog (mouse); FLJ12541; MCOPS9; PP14296; stimulated by retinoic acid gene 6 homolog; STRA6 antibody; stimulated by retinoic acid gene 6 homolog (mouse) antibody; FLJ12541 antibody; MCOPS9 antibody; PP14296 antibody; stimulated by retinoic acid gene 6 homolog antibody; STRA6 (mouse, rat)
Antibody/Peptide Pairs
STRA6 peptide (MBS426933) is used for blocking the activity of STRA6 antibody (MBS421539)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence
QAFRKAALTS AKAN
Clonality
Polyclonal
Host
Goat
Species Reactivity
Tested: Mouse; Expected from sequence similarity: Mouse, Rat
Purity/Purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Form/Format
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Concentration
100ug specific antibody in 200ul (lot specific)
Immunogen
Peptide with sequence C-QAFRKAALTSAKAN, from the C Terminus of the protein sequence according to NP_033317.1; NP_001025095.1.
Epitope
C Terminus
Preparation and Storage
Aliquot and store at -20 degree C. Minimize freezing and thawing.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of anti-STRA6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-STRA6 antibody
Peptide ELISA (EIA), Western Blot (WB)
Application Notes for anti-STRA6 antibody
Peptide ELISA: Antibody detection limit dilution 1: 32000.
Western Blot: Approx 90kDa band observed in lysates of 3T3-L1 adipocytes that is reduced by stra6 siRNA. The 90kDa band is stained after retrovirally overexpressing Mouse Stra6 and not after overexpressing Human Stra6 in 3T3 preadipocytes (calculated MW of 73.8kDa according to NP_001025095.1). Please note a non-specific band of ~80kDa. Recommended concentration: 1-3ug/ml.

Western Blot (WB) of anti-STRA6 antibody
Staining of 3T3-L1 lysates (35ug protein in RIPA buffer). Primary incubation was 3 hour. Detected by chemiluminescence.
anti-STRA6 antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for STRA6. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI Related Accession #
Manufactured in an ISO 9001:2015 Certified Laboratory.NP_001025095.1[Other Products]
NCBI GenBank Nucleotide #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
73,775 Da
NCBI Official Full Name
stimulated by retinoic acid gene 6
NCBI Official Synonym Full Names
stimulated by retinoic acid gene 6
NCBI Official Symbol
Stra6  [Similar Products]
NCBI Official Synonym Symbols
AI891933
  [Similar Products]
NCBI Protein Information
stimulated by retinoic acid gene 6 protein
UniProt Protein Name
Stimulated by retinoic acid gene 6 protein
UniProt Synonym Protein Names
Retinoic acid-responsive protein
UniProt Gene Name
Stra6  [Similar Products]
UniProt Entry Name
STRA6_MOUSE
UniProt Comments for STRA6
STRA6: May act as a high-affinity cell-surface receptor for the complex retinol-retinol binding protein (RBP/RBP4). Acts by removing retinol from RBP/RBP4 and transports it across the plasma membrane, where it can be metabolized. This mechanism does not depend on endocytosis. Binds to RBP/RBP4 with high affinity. Increases cellular retinol uptake from the retinol-RBP complex. Defects in STRA6 are the cause of microphthalmia syndromic type 9 (MCOPS9); also called Matthew-Wood syndrome or Spear syndrome. Microphthalmia is a clinically heterogeneous disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues (anophthalmia). In many cases, microphthalmia/anophthalmia occurs in association with syndromes that include non-ocular abnormalities. MCOPS9 is a rare clinical entity including as main characteristics anophthalmia or severe microphthalmia, and pulmonary hypoplasia or aplasia. Mutations in STRA6 may be a cause of isolated colobomatous microphthalmia, a disorder of the eye characterized by an abnormally small ocular globe. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Membrane protein, multi-pass

Cellular Component: integral to membrane; membrane; plasma membrane; protein complex

Molecular Function: protein binding; receptor activity; vitamin transporter activity

Biological Process: adrenal gland development; alveolus development; artery morphogenesis; blood vessel development; cognition; developmental growth; digestive tract morphogenesis; ear development; embryonic gut development; feeding behavior; female genitalia development; heart development; kidney development; learning; lung development; neuromuscular process; nose morphogenesis; positive regulation of behavior; positive regulation of JAK-STAT cascade; smooth muscle development; transport; vocal learning
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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