NP_001317449.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
trinucleotide repeat-containing gene 6A protein isoform 2
NCBI Official Synonym Full Names
trinucleotide repeat containing 6A
NCBI Protein Information
trinucleotide repeat-containing gene 6A protein
UniProt Protein Name
Trinucleotide repeat-containing gene 6A protein
UniProt Synonym Protein Names
CAG repeat protein 26; EMSY interactor protein; GW182 autoantigen; Protein GW1; Glycine-tryptophan protein of 182 kDa
UniProt Synonym Gene Names
NCBI Summary for TNRC6A
This gene encodes a member of the trinucleotide repeat containing 6 protein family. The protein functions in post-transcriptional gene silencing through the RNA interference (RNAi) and microRNA pathways. The protein associates with messenger RNAs and Argonaute proteins in cytoplasmic bodies known as GW-bodies or P-bodies. Inhibiting expression of this gene delocalizes other GW-body proteins and impairs RNAi and microRNA-induced gene silencing. [provided by RefSeq, Jul 2008]
UniProt Comments for TNRC6A
Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs). Required for miRNA-dependent repression of translation and for siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins. As a scaffolding protein, associates with argonaute proteins bound to partially complementary mRNAs, and can simultaneously recruit CCR4-NOT and PAN deadenylase complexes.
Research Articles on TNRC6A
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Products associated with anti-TNRC6A antibody
Pathways associated with anti-TNRC6A antibody
Diseases associated with anti-TNRC6A antibody
Organs/Tissues associated with anti-TNRC6A antibody
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