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anti-TOSO antibody :: Rabbit TOSO Polyclonal Antibody

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Catalog # MBS221472
Unit / Price
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  0.1 mg  /  $375 +1 FREE 8GB USB
Testing Data #1
Product Name

TOSO, Polyclonal Antibody

Popular Item
Full Product Name

RABBIT ANTI HUMAN TOSO (C-TERMINAL)

Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
606015
3D Structure
ModBase 3D Structure for O60667
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Mouse (Expected from Sequence), Rat (Expected from Sequence)
Specificity
This item detects an epitope within the C-terminal (CT) region of human Toso, also known as Fas Apoptotic Inhibitory Molecule 3 (FAIM3). Toso is expressed by lymphoid and haematopoietic cells and is up-regulated by T-cell activation. Toso expressing cells have increased resistance to Fas-, FADD-, and TNFalpha-induced apoptosis. Toso is membrane bound, and is thought to directly bind to FADD, disrupting DISC formation and thus inhibiting caspase-8 activation.

Toso is a potential proto-oncogene, and could be a therapeutic target for use in the treatment of autoimmune diseases. Despite its predicted molecular weight, Toso often migrates at 60kDa in SDS PAGE.
Form/Format
Purified
Purified IgG - liquid
Concentration
IgG concentration 0.5 mg/ml (lot specific)
Perservative Stabilisers
0.02% Sodium Azide
Immunogen
A 13 amino acid peptide from near the carboxy terminus of human Toso.
Buffer Solution
Antiserum Preparation
Antisera to human Toso were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography.
Target Species
Human
Preparation and Storage
Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
Other Notes
Small volumes of anti-TOSO antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-TOSO antibody
MBS221472 detects an epitope within the C-terminal (CT) region of human Toso, also known as Fas Apoptotic Inhibitory Molecule 3 (FAIM3). Toso is expressed by lymphoid and haematopoietic cells and is up-regulated by T-cell activation. Toso expressing cells have increased resistance to Fas-, FADD-, and TNFalpha-induced apoptosis. Toso is membrane bound, and is thought to directly bind to FADD, disrupting DISC formation and thus inhibiting caspase-8 activation. Toso is a potential proto-oncogene, and could be a therapeutic target for use in the treatment of autoimmune diseases. Despite its predicted molecular weight, Toso often migrates at 60kDa in SDS PAGE.
Applications Tested/Suitable for anti-TOSO antibody
Western Blot (WB)
Application Notes for anti-TOSO antibody
Western Blot: This item detects a band of approximately 43kDa in human lung tissue lysate.
Western Blotting: Minimum Dilution: 1; Maximum Dilution: 2ug/ml

Testing Data #1 of anti-TOSO antibody
Western blot analysis of human lung lysate probed with Rabbit anti Human TOSO (MBS221472)
anti-TOSO antibody Testing Data #1 image
NCBI/Uniprot data below describe general gene information for TOSO. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
33,828 Da
NCBI Official Full Name
fas apoptotic inhibitory molecule 3 isoform b
NCBI Official Synonym Full Names
Fas apoptotic inhibitory molecule 3
NCBI Official Symbol
FAIM3  [Similar Products]
NCBI Official Synonym Symbols
FCMR; TOSO
  [Similar Products]
NCBI Protein Information
fas apoptotic inhibitory molecule 3; Fc mu receptor; IgM Fc receptor; immunoglobulin mu Fc receptor; regulator of Fas-induced apoptosis Toso
UniProt Protein Name
Fas apoptotic inhibitory molecule 3
UniProt Synonym Protein Names
Regulator of Fas-induced apoptosis Toso
UniProt Gene Name
FAIM3  [Similar Products]
UniProt Synonym Gene Names
UniProt Entry Name
FAIM3_HUMAN
NCBI Summary for TOSO
Fc receptors specifically bind to the Fc region of immunoglobulins (Igs) to mediate the unique functions of each Ig class. FAIM3 encodes an Fc receptor for IgM (see MIM 147020) (Kubagawa et al., 2009 [PubMed 19858324]; Shima et al., 2010 [PubMed 20042454]).[supplied by OMIM, Jul 2010]
UniProt Comments for TOSO
FAIM3: May play a role in the immune system processes. Protects cells from FAS-, TNF alpha- and FADD-induced apoptosis without increasing expression of the inhibitors of apoptosis BCL2 and BCLXL. Seems to activate an inhibitory pathway that prevents CASP8 activation following FAS stimulation, rather than blocking apoptotic signals downstream. May inhibit FAS-induced apoptosis by preventing CASP8 processing through CFLAR up-regulation. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Apoptosis

Chromosomal Location of Human Ortholog: 1q32.1

Cellular Component: extracellular region; integral to membrane

Biological Process: immune system process; cellular defense response; negative regulation of apoptosis
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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