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anti-IL15 antibody :: Rabbit anti-Murine IL-15 IL15 Polyclonal Antibody

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Catalog # MBS534575
Unit / Price
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  0.2 mg  /  $490 +1 FREE 8GB USB
Western Blot
Product Name

IL15, Polyclonal Antibody

Full Product Name

IL15 antibody

Product Synonym Names
Polyclonal IL15; Anti-IL15; IL-15; IL 15; IL15; Interleukin
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
600554
3D Structure
ModBase 3D Structure for P40933
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Murine IL-15
Form/Format
Supplied as a lyophilized Potein A purified rabbit IgG with 0.1% NaN3. Reconstitue in distilled water.
Biological Significance
Interleukin 15 (IL-15) is a cytokine with structural similarity to IL-2. Like IL-2, IL-15 binds to and signals through the IL-2/IL-15 beta chain (CD122) and the common gamma chain (gamma-C, CD132). IL-15 is secreted by mononuclear phagocytes (and some other cells) following infection by virus(es). This cytokine induces cell proliferation of natural killer cells; cells of the innate immune system whose principal role is to kill virally infected cells.
Immunogen
IL15 antibody was raised in rabbit using E Coli-expressed murine IL-15 as the immunogen.
Preparation and Storage
Store at 4 degree C for short term storage. Aliquot and store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.
Other Notes
Small volumes of anti-IL15 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-IL15 antibody
Affinity purified Rabbit polyclonal IL15 antibody
Applications Tested/Suitable for anti-IL15 antibody
Western Blot (WB)
Application Notes for anti-IL15 antibody
WB: 1:5,000

Western Blot of anti-IL15 antibody
Western Blot analysis using IL15 antibody
Lane 1 - mIL15 transfectant; Lane 2 - Control; Lane 3 - Marker
anti-IL15 antibody Western Blot (WB) image
NCBI/Uniprot data below describe general gene information for IL15. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
14,912 Da
NCBI Official Synonym Full Names
interleukin 15
NCBI Official Symbol
NCBI Official Synonym Symbols
IL-15
  [Similar Products]
NCBI Protein Information
interleukin-15
UniProt Protein Name
Interleukin-15
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
IL-15  [Similar Products]
UniProt Entry Name
IL15_HUMAN
NCBI Summary for IL15
The protein encoded by this gene is a cytokine that regulates T and natural killer cell activation and proliferation. This cytokine and interleukine 2 share many biological activities. They are found to bind common hematopoietin receptor subunits, and may compete for the same receptor, and thus negatively regulate each other's activity. The number of CD8+ memory cells is shown to be controlled by a balance between this cytokine and IL2. This cytokine induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6. Studies of the mouse counterpart suggested that this cytokine may increase the expression of apoptosis inhibitor BCL2L1/BCL-x(L), possibly through the transcription activation activity of STAT6, and thus prevent apoptosis. Alternatively spliced transcript variants of this gene have been reported. [provided by RefSeq, Feb 2011]
UniProt Comments for IL15
IL15: Cytokine that stimulates the proliferation of T- lymphocytes. Stimulation by IL-15 requires interaction of IL-15 with components of IL-2R, including IL-2R beta and probably IL-2R gamma but not IL-2R alpha. Belongs to the IL-15/IL-21 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cytokine; Cell cycle regulation; Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 4q31

Cellular Component: nucleoplasm; Golgi apparatus; extracellular space; cell surface; membrane; integral to plasma membrane; cytoplasm; extracellular region; endosome

Molecular Function: protein binding; hematopoietin/interferon-class (D200-domain) cytokine receptor binding; cytokine activity

Biological Process: positive regulation of interleukin-17 production; NK T cell proliferation; positive regulation of natural killer cell proliferation; positive regulation of immune response; negative regulation of smooth muscle cell proliferation; cell maturation; signal transduction; lymph node development; positive regulation of tyrosine phosphorylation of Stat3 protein; positive regulation of natural killer cell differentiation; extrathymic T cell selection; positive regulation of tissue remodeling; skeletal muscle atrophy; cell-cell signaling; natural killer cell differentiation; positive regulation of cell proliferation; positive regulation of T cell proliferation; regulation of T cell differentiation; immune response; inflammatory response; regulation of defense response to virus by host; hyaluronan metabolic process; positive regulation of inflammatory response; aging
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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