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anti-UCP2 antibody :: Rabbit anti-Murine UCP2 Polyclonal Antibody

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Catalog # MBS535066
Unit / Price
  0.1 mg  /  $745 +1 FREE 8GB USB
anti-UCP2 antibody
Product Name

UCP2, Polyclonal Antibody

Also Known As

UCP2 antibody

Product Synonym Names
Polyclonal UCP2; Anti-UCP2; UCP 2; Uncoupling Protein 2; UCP2; UCP-2; UCP -2
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
309
OMIM
601693
3D Structure
ModBase 3D Structure for P55851
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Murine
Purity/Purification
UCP2 antibody was purified by affinity chromatography.
Form/Format
Affinity purified antibody lyophilized from 100mM Tris, pH 7.5, with 0.2% BSA, and 0.05% NaN3. Reconstitute in 100 ul of water, do not dilute further until ready to use.
Biological Significance
Uncoupling proteins (UCP1-5) are a family of mitochondria transport proteins that play a critical role in thermoregulatory heat production and maintenance of basal metabolic rate. UCP3 is predicted to contain 6 transmembrane domains. The UCP3S lacks the 6th transmembrane domain and it is only 275 aa long. Mouse/rat UCP2 is A 309 AA (human 309 aa chromosome 7; ~95% homology) mitochondrial uncoupling protein. UCP2 has wide tissue distribution in mouse tissues (brain, kidney, liver, brown adipose tissue, heart, and muscle). UCP2 may play a critical role in energy balance, body weight, and thermoregulation.
Immunogen
UCP2 antibody was raised in rabbit using a 14 amino acid peptide from mouse UCP2 as the immunogen.
Preparation and Storage
Store at 4 degree C for short term storage. Aliquot and store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.
Other Notes
Small volumes of anti-UCP2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-UCP2 antibody
Rabbit polyclonal UCP2 antibody
Product Categories/Family for anti-UCP2 antibody
Applications Tested/Suitable for anti-UCP2 antibody
ELISA (EIA), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB)
Application Notes for anti-UCP2 antibody
ELISA: 1:10,000-1:100,000
IF: 2-20 ug/ml
WB: 1-10 ug/ml
NCBI/Uniprot data below describe general gene information for UCP2. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
33,229 Da
NCBI Official Full Name
UCP2
NCBI Official Synonym Full Names
uncoupling protein 2 (mitochondrial, proton carrier)
NCBI Official Symbol
NCBI Official Synonym Symbols
UCPH; BMIQ4; SLC25A8
  [Similar Products]
NCBI Protein Information
mitochondrial uncoupling protein 2
UniProt Protein Name
Mitochondrial uncoupling protein 2
UniProt Synonym Protein Names
Solute carrier family 25 member 8; UCPH
UniProt Gene Name
UniProt Synonym Gene Names
SLC25A8; UCP 2  [Similar Products]
UniProt Entry Name
UCP2_HUMAN
NCBI Summary for UCP2
Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is expressed in many tissues, with the greatest expression in skeletal muscle. It is thought to play a role in nonshivering thermogenesis, obesity and diabetes. Chromosomal order is 5'-UCP3-UCP2-3'. [provided by RefSeq, Jul 2008]
UniProt Comments for UCP2
UCP2: UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat. Belongs to the mitochondrial carrier family.

Protein type: Membrane protein, integral; Mitochondrial; Membrane protein, multi-pass; Transporter

Chromosomal Location of Human Ortholog: 11q13

Cellular Component: mitochondrial inner membrane; integral to membrane

Biological Process: cellular metabolic process; response to superoxide; proton transport; regulation of mitochondrial membrane potential; cellular response to insulin stimulus; cellular response to amino acid starvation; transport; response to hypoxia; female pregnancy; negative regulation of apoptosis; aging; mitochondrial transport

Disease: Body Mass Index Quantitative Trait Locus 4
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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