NP_001027458.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
53,042 Da
NCBI Official Full Name
nuclear receptor subfamily 2 group C member 1 isoform b
NCBI Official Synonym Full Names
nuclear receptor subfamily 2 group C member 1
NCBI Official Synonym Symbols
NCBI Protein Information
nuclear receptor subfamily 2 group C member 1
UniProt Protein Name
Nuclear receptor subfamily 2 group C member 1
UniProt Synonym Protein Names
Orphan nuclear receptor TR2; Testicular receptor 2
UniProt Synonym Gene Names
UniProt Entry Name
NR2C1_HUMAN
NCBI Summary for NR2C1
This gene encodes a nuclear hormone receptor characterized by a highly conserved DNA binding domain (DBD), a variable hinge region, and a carboxy-terminal ligand binding domain (LBD) that is typical for all members of the steroid/thyroid hormone receptor superfamily. This protein also belongs to a large family of ligand-inducible transcription factors that regulate gene expression by binding to specific DNA sequences within promoters of target genes. Multiple alternatively spliced transcript variants have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]
UniProt Comments for NR2C1
NR2C1: Orphan nuclear receptor. Binds the IR7 element in the promoter of its own gene in an autoregulatory negative feedback mechanism. Primarily repressor of a broad range of genes. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences. Together with NR2C2, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription. Also activator of OCT4 gene expression. May be involved in stem cell proliferation and differentiation. Mediator of retinoic acid- regulated preadipocyte proliferation. Belongs to the nuclear hormone receptor family. NR2 subfamily. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Nuclear receptor; DNA-binding
Chromosomal Location of Human Ortholog: 12q22
Cellular Component: nucleoplasm; PML body
Molecular Function: DNA binding; histone deacetylase binding; protein binding; protein homodimerization activity; receptor activity; steroid hormone receptor activity; zinc ion binding
Biological Process: gene expression; negative regulation of transcription from RNA polymerase II promoter; positive regulation of retinoic acid receptor signaling pathway; steroid hormone mediated signaling; transcription initiation from RNA polymerase II promoter
Research Articles on NR2C1
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Products associated with anti-NR2C1 antibody
Pathways associated with anti-NR2C1 antibody
Diseases associated with anti-NR2C1 antibody
Organs/Tissues associated with anti-NR2C1 antibody
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