NP_073728.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
period circadian protein homolog 2
NCBI Official Synonym Full Names
period circadian clock 2
NCBI Protein Information
period circadian protein homolog 2
UniProt Protein Name
Period circadian protein homolog 2
UniProt Synonym Protein Names
Circadian clock protein PERIOD 2
UniProt Synonym Gene Names
UniProt Entry Name
PER2_HUMAN
NCBI Summary for PER2
This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene may increase the risk of getting certain cancers and have been linked to sleep disorders. [provided by RefSeq, Jan 2014]
UniProt Comments for PER2
PER2: a transcription factor belonging to the basic helix-loop-helix (bHLH) family. A member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. Circadian expression in the suprachiasmatic nucleus continues in constant darkness, and a shift in the light/dark cycle evokes a proportional shift of gene expression in the suprachiasmatic nucleus. Behaves as a negative element in circadian transcriptional loop. Does not appear to bind DNA, suggesting indirect transcriptional inhibition. Expression oscillates with a 24 hr rhythm in the suprachiasmatic nucleus and the whole eyes. Oscillations are maintained under constant darkness and are responsive to changes of the light/dark cycles. There is a 4 hour time delay between per1 and per2 oscillations. The expression rhythms appear to originate from retina.
Protein type: Nucleolus; Nuclear receptor co-regulator; Transcription factor
Chromosomal Location of Human Ortholog: 2q37.3
Cellular Component: nucleoplasm; perinuclear region of cytoplasm; cytoplasm; nucleolus; nucleus
Molecular Function: signal transducer activity; ubiquitin binding; protein binding; histone deacetylase binding; transcription coactivator activity; kinase binding; nuclear hormone receptor binding
Biological Process: circadian rhythm; glycogen biosynthetic process; transcription, DNA-dependent; regulation of cell cycle; negative regulation of transcription from RNA polymerase II promoter; fatty acid metabolic process; signal transduction; regulation of circadian rhythm; regulation of glutamate uptake during transmission of nerve impulse; gluconeogenesis; regulation of neurogenesis; regulation of vasoconstriction; white fat cell differentiation; lactate biosynthetic process; negative regulation of protein ubiquitination; negative regulation of circadian rhythm; circadian regulation of gene expression; negative regulation of transcription, DNA-dependent; regulation of insulin secretion
Disease: Advanced Sleep Phase Syndrome, Familial, 1
Research Articles on PER2
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Products associated with anti-PER2 antibody
Pathways associated with anti-PER2 antibody
Diseases associated with anti-PER2 antibody
Organs/Tissues associated with anti-PER2 antibody
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