NP_002681.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
NCBI Official Full Name
DNA polymerase beta
NCBI Official Synonym Full Names
DNA polymerase beta
NCBI Protein Information
DNA polymerase beta
UniProt Protein Name
DNA polymerase beta
UniProt Entry Name
DPOLB_HUMAN
NCBI Summary for POLB
The protein encoded by this gene is a DNA polymerase involved in base excision and repair, also called gap-filling DNA synthesis. The encoded protein, acting as a monomer, is normally found in the cytoplasm, but it translocates to the nucleus upon DNA damage. Several transcript variants of this gene exist, but the full-length nature of only one has been described to date. [provided by RefSeq, Sep 2011]
UniProt Comments for POLB
POLB: Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases. Monomer. Interacts with APEX1, HUWE1/ARF-BP1, STUB1/CHIP and USP47. Belongs to the DNA polymerase type-X family.
Protein type: EC 2.7.7.7; Transferase; Lyase; DNA replication; DNA repair, damage
Chromosomal Location of Human Ortholog: 8p11.2
Cellular Component: nucleoplasm; microtubule; spindle microtubule; cytoplasm; nucleus
Molecular Function: protein binding; enzyme binding; metal ion binding; microtubule binding; damaged DNA binding; DNA-directed DNA polymerase activity; lyase activity
Biological Process: base-excision repair, gap-filling; neuron apoptosis; response to ethanol; DNA damage response, signal transduction resulting in induction of apoptosis; base-excision repair; pyrimidine dimer repair; nucleotide-excision repair, DNA gap filling; DNA repair; DNA-dependent DNA replication; response to DNA damage stimulus
Research Articles on POLB
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Products associated with anti-POLB antibody
Pathways associated with anti-POLB antibody
Diseases associated with anti-POLB antibody
Organs/Tissues associated with anti-POLB antibody
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