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anti-CASP1 antibody :: Rabbit anti-Porcine Caspase 1 (CASP1) Polyclonal Antibody

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Catalog # MBS2002145 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
Unit / Price
Scan QR to view Datasheet
  0.01 mg  /  $115 +1 FREE 8GB USB
  0.02 mg  /  $135 +1 FREE 8GB USB
  0.05 mg  /  $195 +1 FREE 8GB USB
  0.1 mg  /  $250 +1 FREE 8GB USB
  0.2 mg  /  $385 +1 FREE 8GB USB
  1 mg  /  $910 +1 FREE 8GB USB
Product Name

Caspase 1 (CASP1), Polyclonal Antibody

Popular Item
Full Product Name

Polyclonal Antibody to Caspase 1 (CASP1)

Matching Pairs
Unconjugated Antibody: Caspase 1 (CASP1) (MBS2002145)
Biotin Conjugated Antibody: Caspase 1 (CASP1) (MBS2005384)
Matching Pairs
Matching Pairs
Unconjugated Antibody: Caspase 1 (CASP1) (MBS2002145)
APC-CY7 Conjugated Antibody: Caspase 1 (CASP1) (MBS2056877)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence
Antigen: The target protein is fused with N-terminal His-Tag and its sequence is listed below.
MGHHHHHHSG SEF-N PVKPASSEPR GSLKLCPPDI AQRLWKEKSA EIYPIMGKSI RTRLALIICN TEFENLPRRD GADVDIRDMK ILLEDLGYSV DVRENLTASD MAIELKAFAA RPEHKSSDST FLVLMSHGIQ AGICGKKYSE EVPDVLEVNT VFQILNTLNC PSLKDKPKVI IIQACRGEKQ GVVWIKD
3D Structure
ModBase 3D Structure for Q9N2I1
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Porcine
Specificity
The antibody is a rabbit polyclonal antibody raised against CASP1. It has been selected for its ability to recognize CASP1 in immunohistochemical staining andwestern blotting.
Purity/Purification
Affinity Chromatography
Form/Format
Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3,50% glycerol.
Concentration
200ug/ml (lot specific)
Immunogen
Recombinant CASP1 (Asn120~Asp297) expressed in E.coli.
Conjugated Antibody
The APC conjugated antibody version of this item is also available as catalog #MBS2056879
Preparation and Storage
Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
ISO Certification
Manufactured in an ISO 9001:2008 and ISO 13485:2003 Certified Laboratory.
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.
Other Notes
Small volumes of anti-CASP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-CASP1 antibody
Applications Tested/Suitable for anti-CASP1 antibody
Immunocytochemistry (ICC), Immunohistochemistry (IHC) - Formalin/Paraffin, ELISA (EIA), Western Blot (WB)
Application Notes for anti-CASP1 antibody
Western blotting: 1:100-400
Immunocytochemistry in formalin fixed cells: 1:100-500
Immunohistochemistry in formalin fixed frozen section: 1:100-500
Immunohistochemistry in paraffin section: 1:50-200
Enzyme-linked Immunosorbent Assay: 1:100-200

Western Blot (WB) of anti-CASP1 antibody
Western Blot: Sample. Lane1: Porcine Spleen Tissue ; Lane2: Porcine Lung Tissue; Lane3: Human Hela Cells; Lane4: Human Raji Cells.
anti-CASP1 antibody Western Blot (WB) (WB) image
Western Blot (WB) of anti-CASP1 antibody
Western Blot: Sample: Recombinant protein.
anti-CASP1 antibody Western Blot (WB) (WB) image
Knockout Validation of anti-CASP1 antibody
Knockout Validation: Lane 1: Wild-type Raji cell lysate;;Lane 2: CASP1 knockout Raji cell lysate;;Predicted MW: 10,30,35,43,45kDa ;Observed MW: 42kDa;Primary Ab: 5ug/ml Rabbit Anti-Porcine CASP1 Antibody;Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody;(#MBS2086047)
anti-CASP1 antibody Knockout Validation image
NCBI/Uniprot data below describe general gene information for CASP1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Related Accession #
Molecular Weight
44,882 Da
NCBI Official Full Name
caspase-1
NCBI Official Symbol
CASP1  [Similar Products]
NCBI Protein Information
caspase-1
UniProt Protein Name
Caspase-1
UniProt Synonym Protein Names
Interleukin-1 beta convertase; IL-1BC
UniProt Gene Name
CASP1  [Similar Products]
UniProt Synonym Gene Names
IL1BC; CASP-1; IL-1BC; ICE; IL-1 beta-converting enzyme  [Similar Products]
UniProt Comments for CASP1
Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of MB21D1/cGAS, rendering it inactive.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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