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anti-TF antibody :: Cavia anti-Rabbit Tissue Factor (TF) Polyclonal Antibody

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Catalog # MBS2013793 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
Unit / Price
  0.1 mg  /  $255 +1 FREE 8GB USB
anti-TF antibody
Product Name

Tissue Factor (TF), Polyclonal Antibody

Popular Item
Full Product Name

FITC-linked Antibody to Tissue Factor (TF)

Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 1; NC_000001.10 (94994732..95007413, complement). Location: 1p22-p21
OMIM
134390
3D Structure
ModBase 3D Structure for P13726
Clonality
Polyclonal
Isotype
IgG
Host
Cavia
Species Reactivity
Rabbit
Specificity
The antibody is a cavia polyclonal antibody raised against tissue factor. It has been selected for its ability to recognize tissue factor in immunohistochemical staining and western blotting.
Purity/Purification
Affinity Chromatography
Concentration
200ug/ml (lot specific)
Immunogen
Tissue factor, Rabbit. Recombinant tissue factor (Ala33~Ala292) with two N-terminal Tags, His-tag and S-tag expressed in E Coli
Conjugation
FITC
Preparation and Storage
Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
ISO Certification
Manufactured in an ISO 9001:2008 and ISO 13485:2003 Certified Laboratory.
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.
Other Notes
Small volumes of anti-TF antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-TF antibody
Applications Tested/Suitable for anti-TF antibody
Immunohistochemistry (IHC) Formalin/Paraffin, Immunocytochemistry (ICC), Western Blot (WB), ELISA (EIA)
Application Notes for anti-TF antibody
Western Blot: 1:50-400
ICC in formalin fixed cells: 1:50-500
IHC in formalin fixed frozen section||1:50-500
IHC in paraffin section: 1:10-100
ELISA: 1:100-200
NCBI/Uniprot data below describe general gene information for TF. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
33,068 Da
NCBI Official Full Name
tissue factor
NCBI Official Synonym Full Names
coagulation factor III (thromboplastin, tissue factor)
NCBI Official Symbol
NCBI Official Synonym Symbols
TF; TFA; CD142
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NCBI Protein Information
tissue factor
UniProt Protein Name
Tissue factor
UniProt Synonym Protein Names
Coagulation factor III; Thromboplastin
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
UniProt Entry Name
TF_HUMAN
NCBI Summary for TF
This gene encodes coagulation factor III which is a cell surface glycoprotein. This factor enables cells to initiate the blood coagulation cascades, and it functions as the high-affinity receptor for the coagulation factor VII. The resulting complex provides a catalytic event that is responsible for initiation of the coagulation protease cascades by specific limited proteolysis. Unlike the other cofactors of these protease cascades, which circulate as nonfunctional precursors, this factor is a potent initiator that is fully functional when expressed on cell surfaces. There are 3 distinct domains of this factor: extracellular, transmembrane, and cytoplasmic. This protein is the only one in the coagulation pathway for which a congenital deficiency has not been described. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
UniProt Comments for TF
F3: Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited protolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade. Interacts with HSPE; the interaction, inhibited by heparin, promotes the generation of activated factor X and activates coagulation in the presence of activated factor VII. TF expression is highly dependent upon cell type. TF can also be induced by the inflammatory mediators interleukin 1 and TNF-alpha, as well as by endotoxin, to appear on monocytes and vascular endothelial cells as a component of cellular immune response. Lung, placenta and pancreas. Belongs to the tissue factor family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell surface; Membrane protein, integral

Chromosomal Location of Human Ortholog: 1p22-p21

Cellular Component: extracellular matrix; extracellular space; cell surface; integral to membrane; plasma membrane

Molecular Function: hematopoietin/interferon-class (D200-domain) cytokine receptor activity; protein binding; protease binding; phospholipid binding

Biological Process: caspase activation; activation of blood coagulation via clotting cascade; positive regulation of protein kinase B signaling cascade; activation of plasma proteins during acute inflammatory response; positive regulation of angiogenesis; blood coagulation, extrinsic pathway; positive regulation of positive chemotaxis; cytokine and chemokine mediated signaling pathway; positive regulation of endothelial cell proliferation; blood coagulation; positive regulation of cell migration
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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