P20339.2
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
22,178 Da
NCBI Official Full Name
Ras-related protein Rab-5A
NCBI Official Synonym Full Names
RAB5A, member RAS oncogene family
NCBI Official Synonym Symbols
NCBI Protein Information
ras-related protein Rab-5A
UniProt Protein Name
Ras-related protein Rab-5A
UniProt Synonym Gene Names
UniProt Entry Name
RAB5A_HUMAN
UniProt Comments for Ras-related protein Rab-5
RAB5A: Required for the fusion of plasma membranes and early endosomes. Contributes to the regulation of filopodia extension. Binds EEA1. Interacts with RIN1 and GAPVD1, which regulate its pathway, probably by acting as a GEF. Interacts with ALS2CL, RABEP1, SUN2, ZFYVE20 and RUFY1. Interacts with SGSM1 and SGSM3. Interacts with PIK3CB. Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP. Belongs to the small GTPase superfamily. Rab family.
Protein type: G protein, monomeric; Motility/polarity/chemotaxis; G protein; G protein, monomeric, Rab
Chromosomal Location of Human Ortholog: 3p24-p22
Cellular Component: actin cytoskeleton; axon; cell soma; cytoplasm; cytosol; dendrite; early endosome; endocytic vesicle; endosome; endosome membrane; lipid raft; melanosome; nerve terminal; phagocytic vesicle; plasma membrane; ruffle; synaptic vesicle; terminal button
Molecular Function: GDP binding; GTP binding; GTPase activity; protein binding
Biological Process: blood coagulation; early endosome to late endosome transport; endocytosis; positive regulation of exocytosis; protein transport; regulation of endocytosis; regulation of endosome size; regulation of filopodium formation; small GTPase mediated signal transduction
Research Articles on Ras-related protein Rab-5
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Products associated with anti-Ras-related protein Rab-5 antibody
Pathways associated with anti-Ras-related protein Rab-5 antibody
Diseases associated with anti-Ras-related protein Rab-5 antibody
Organs/Tissues associated with anti-Ras-related protein Rab-5 antibody
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