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anti-HSD11b1 antibody :: Rabbit anti-Rat 11-Beta-Hydroxysteroid Dehydrogenase Type 1 (HSD11b1) Polyclonal Antibody

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Catalog # MBS2064426 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
Unit / Price
Scan QR to view Datasheet
  0.01 mg  /  $170 +1 FREE 8GB USB
  0.02 mg  /  $205 +1 FREE 8GB USB
  0.05 mg  /  $325 +1 FREE 8GB USB
  0.1 mg  /  $450 +1 FREE 8GB USB
  0.2 mg  /  $700 +1 FREE 8GB USB
  1 mg  /  $1,700 +2 FREE 8GB USB
anti-HSD11b1 antibody
Product Name

11-Beta-Hydroxysteroid Dehydrogenase Type 1 (HSD11b1), Polyclonal Antibody

Full Product Name

Cy3-Linked Polyclonal Antibody to 11-Beta-Hydroxysteroid Dehydrogenase Type 1 (HSD11b1)

Product Synonym Names
11DH; 11-beta-HSD1; HDL; HSD11; HSD11B; HSD11L; SDR26C1; Corticosteroid 11-beta-dehydrogenase isozyme 1; Short Chain Dehydrogenase/Reductase Family 26C, Member 1
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Rat
Concentration
200ug/ml (lot specific)
Immunogen
HSD11b1 (Met1~Asn288)
Conjugation
Cy3
Unconjugated Antibody
The unconjugated antibody version of this item is also available as catalog #MBS2026098
ISO Certification
Manufactured in an ISO 9001:2008 and ISO 13485:2003 Certified Laboratory.
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.
Other Notes
Small volumes of anti-HSD11b1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-HSD11b1 antibody
Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin/Paraffin, ELISA (ELISA)
NCBI/Uniprot data below describe general gene information for HSD11b1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
32,401 Da
NCBI Official Full Name
11-beta hydroxysteroid dehydrogenase type 1
NCBI Official Synonym Full Names
hydroxysteroid 11-beta dehydrogenase 1
NCBI Official Symbol
HSD11B1  [Similar Products]
NCBI Official Synonym Symbols
HDL; 11-DH; HSD11; HSD11B; HSD11L; CORTRD2; SDR26C1; 11-beta-HSD1
  [Similar Products]
NCBI Protein Information
corticosteroid 11-beta-dehydrogenase isozyme 1
UniProt Protein Name
Corticosteroid 11-beta-dehydrogenase isozyme 1
UniProt Synonym Protein Names
11-beta-hydroxysteroid dehydrogenase 1; 11-DH; 11-beta-HSD1; Short chain dehydrogenase/reductase family 26C member 1
UniProt Gene Name
HSD11B1  [Similar Products]
UniProt Synonym Gene Names
HSD11; HSD11L; SDR26C1; 11-DH; 11-beta-HSD1  [Similar Products]
NCBI Summary for HSD11b1
The protein encoded by this gene is a microsomal enzyme that catalyzes the conversion of the stress hormone cortisol to the inactive metabolite cortisone. In addition, the encoded protein can catalyze the reverse reaction, the conversion of cortisone to cortisol. Too much cortisol can lead to central obesity, and a particular variation in this gene has been associated with obesity and insulin resistance in children. Mutations in this gene and H6PD (hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)) are the cause of cortisone reductase deficiency. Alternate splicing results in multiple transcript variants encoding the same protein.[provided by RefSeq, May 2011]
UniProt Comments for HSD11b1
HSD11B1: Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone. Catalyzes reversibly the conversion of 7-ketocholesterol to 7-beta-hydroxycholesterol. In intact cells, the reaction runs only in one direction, from 7- ketocholesterol to 7-beta-hydroxycholesterol. Defects in HSD11B1 are a cause of cortisone reductase deficiency (CRD). In CRD, activation of cortisone to cortisol does not occur, resulting in adrenocorticotropin-mediated androgen excess and a phenotype resembling polycystic ovary syndrome (PCOS). Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Protein type: EC 1.1.1.146; Endoplasmic reticulum; Lipid Metabolism - C21-steroid hormone; Lipid Metabolism - androgen and estrogen; Membrane protein, integral; Nuclear envelope; Oxidoreductase

Chromosomal Location of Human Ortholog: 1q32.2

Cellular Component: endoplasmic reticulum membrane; membrane

Molecular Function: 11-beta-hydroxysteroid dehydrogenase activity

Biological Process: glucocorticoid biosynthetic process

Disease: Cortisone Reductase Deficiency 2
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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