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anti-HSD11b2 antibody :: Rabbit anti-Rat 11-Beta-Hydroxysteroid Dehydrogenase Type 2 (HSD11b2) Polyclonal Antibody

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Catalog # MBS2076067 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
Unit / Price
Scan QR to view Datasheet
  0.01 mg  /  $130 +1 FREE 8GB USB
  0.02 mg  /  $150 +1 FREE 8GB USB
  0.05 mg  /  $225 +1 FREE 8GB USB
  0.1 mg  /  $295 +1 FREE 8GB USB
  0.2 mg  /  $465 +1 FREE 8GB USB
  1 mg  /  $1,115 +1 FREE 8GB USB
anti-HSD11b2 antibody
Product Name

11-Beta-Hydroxysteroid Dehydrogenase Type 2 (HSD11b2), Polyclonal Antibody

Full Product Name

HRP-Linked Polyclonal Antibody to 11-Beta-Hydroxysteroid Dehydrogenase Type 2 (HSD11b2)

Product Synonym Names
AME; AME1; HSD11K; HSD2; SDR9C3; Short Chain Dehydrogenase/Reductase Family 9C, Member 3; NAD-dependent 11-beta-hydroxysteroid dehydrogenase
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
U14631 mRNA
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Rat
Concentration
200ug/ml (lot specific)
Immunogen
HSD11b2 (Leu58~Pro393)
Conjugation
HRP
Unconjugated Antibody
The unconjugated antibody version of this item is also available as catalog #MBS2026283
ISO Certification
Manufactured in an ISO 9001:2008 and ISO 13485:2003 Certified Laboratory.
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.
Other Notes
Small volumes of anti-HSD11b2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-HSD11b2 antibody
Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin/Paraffin, ELISA (ELISA)
NCBI/Uniprot data below describe general gene information for HSD11b2. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
44,127 Da
NCBI Official Full Name
11-beta-hydroxysteroid dehydrogenase type 2
NCBI Official Synonym Full Names
hydroxysteroid 11-beta dehydrogenase 2
NCBI Official Symbol
HSD11B2  [Similar Products]
NCBI Official Synonym Symbols
AME; AME1; HSD2; HSD11K; SDR9C3
  [Similar Products]
NCBI Protein Information
corticosteroid 11-beta-dehydrogenase isozyme 2
UniProt Protein Name
Corticosteroid 11-beta-dehydrogenase isozyme 2
UniProt Synonym Protein Names
11-beta-hydroxysteroid dehydrogenase type 2; 11-DH2; 11-beta-HSD2; 11-beta-hydroxysteroid dehydrogenase type II; 11-HSD type II; 11-beta-HSD type II; NAD-dependent 11-beta-hydroxysteroid dehydrogenase; 11-beta-HSD; Short chain dehydrogenase/reductase family 9C member 3
UniProt Gene Name
HSD11B2  [Similar Products]
UniProt Synonym Gene Names
; 11-DH2; 11-beta-HSD2; 11-HSD type II; 11-beta-HSD type II; 11-beta-HSD  [Similar Products]
NCBI Summary for HSD11b2
There are at least two isozymes of the corticosteroid 11-beta-dehydrogenase, a microsomal enzyme complex responsible for the interconversion of cortisol and cortisone. The type I isozyme has both 11-beta-dehydrogenase (cortisol to cortisone) and 11-oxoreductase (cortisone to cortisol) activities. The type II isozyme, encoded by this gene, has only 11-beta-dehydrogenase activity. In aldosterone-selective epithelial tissues such as the kidney, the type II isozyme catalyzes the glucocorticoid cortisol to the inactive metabolite cortisone, thus preventing illicit activation of the mineralocorticoid receptor. In tissues that do not express the mineralocorticoid receptor, such as the placenta and testis, it protects cells from the growth-inhibiting and/or pro-apoptotic effects of cortisol, particularly during embryonic development. Mutations in this gene cause the syndrome of apparent mineralocorticoid excess and hypertension. [provided by RefSeq, Feb 2010]
UniProt Comments for HSD11b2
HSD11B2: Catalyzes the conversion of cortisol to the inactive metabolite cortisone. Modulates intracellular glucocorticoid levels, thus protecting the nonselective mineralocorticoid receptor from occupation by glucocorticoids. Defects in HSD11B2 are the cause of apparent mineralocorticoid excess (AME). An autosomal recessive form of low-renin hypertension. It is usually diagnosed within the first years of life and is characterized by polyuria and polydipsia, failure to thrive, hypernatremia, severe hypertension with low renin and aldosterone levels, profound hypokalemia with metabolic alkalosis, and most often nephrocalcinosis. Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Protein type: EC 1.1.1.-; Lipid Metabolism - C21-steroid hormone; Lipid Metabolism - androgen and estrogen; Oxidoreductase

Chromosomal Location of Human Ortholog: 16q22.1

Cellular Component: endoplasmic reticulum membrane

Molecular Function: 11-beta-hydroxysteroid dehydrogenase activity

Biological Process: glucocorticoid biosynthetic process

Disease: Apparent Mineralocorticoid Excess
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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