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anti-ADORA3 antibody :: Rabbit anti-Rat Adenosine A3 Receptor Polyclonal Antibody

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Catalog # MBS613614
Unit / Price
  0.1 mL  /  $720 +1 FREE 8GB USB
anti-ADORA3 antibody
Product Name

Adenosine A3 Receptor (ADORA3), Polyclonal Antibody

Also Known As

Adenosine A3 Receptor (A3AR)

Product Synonym Names
Anti -Adenosine A3 Receptor (A3AR)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 1; NC_000001.10 (112025970..112106597, complement). Location: 1p13.2
3D Structure
ModBase 3D Structure for Q6LD47
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Rat
Specificity
Recognizes Adenosine A3 Receptor. Species crossreactivity: The peptide used for making antibodies to rat A3R shows 46% homology (7/15 AA) with human and 20% (3/15 AA) with sheep A3R sequences. Antibody crossreactivity in various species is not established.
Purity/Purification
Serum
Serum
Form/Format
Supplied as a liquid in 0.05% sodium azide, 40% glycerol.
Immunogen
A 15 amino acid sequence corresponding to rat A3R gene. This region corresponds to the 3rd extracellular domain.
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage, store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Other Notes
Small volumes of anti-ADORA3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-ADORA3 antibody
The purine nucleoside adenosine modulates diverse physiological functions including induction of sedation, vasodilatation, suppression of cardiac rate and contractility, neurotransmitter release, inhibition of platelet aggregation and lipolysis. Adenosine released from cells interacts with membrane receptors (adenosine receptors, ARs). Based upon biochemical and pharmacological criteria, ARs have been classified into A1, A2a, A2b and A3. The high affinity receptor A1 inhibits adenyl cyclase via G proteins. A2a receptor is believed to cause vasorelaxation in the coronary artery. Various ARs and their subtypes have recently been cloned from several species. ARs belong to the superfamily of G-protein coupled receptors and predicted to contain 7 transmembrane domains. The N-termini and C-termini are predicted to be extracellular and cytoplasmic, respectively. There is an overall 30% homology among the four ARs. ARs are distributed throughout the body. Gene location of various ARs: A1 (Chromosome 1; q.31.3-32.2); A2a (Chromosome 22); A2b (Chromosome 17; p.11.2-12); A3 (Chromosome 1).
Product Categories/Family for anti-ADORA3 antibody
Applications Tested/Suitable for anti-ADORA3 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-ADORA3 antibody
Suitable for use in ELISA and Western Blot.
Dilution: Western Blot: 1:1000-1:5000
ELISA: 1:10,000-1:50,000 using 50-100ng A3R control peptide per well.
NCBI/Uniprot data below describe general gene information for ADORA3. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
UniProt Primary Accession #
UniProt Related Accession #
Molecular Weight
NCBI Official Full Name
adenosine A3 receptor
NCBI Official Synonym Full Names
adenosine A3 receptor
NCBI Official Symbol
ADORA3  [Similar Products]
NCBI Official Synonym Symbols
A3AR; AD026; bA552M11.5; RP11-552M11.7
  [Similar Products]
NCBI Protein Information
adenosine receptor A3; OTTHUMP00000013476; OTTHUMP00000013479; OTTHUMP00000013739; OTTHUMP00000082917
UniProt Protein Name
Adenosine A3 receptor protein
Protein Family
UniProt Gene Name
adenosine A3 receptor  [Similar Products]
UniProt Entry Name
Q6LD47_HUMAN
NCBI Summary for ADORA3
This gene encodes a protein that belongs to the family of adenosine receptors, which are G-protein-coupled receptors that are involved in a variety of intracellular signaling pathways and physiological functions. The receptor encoded by this gene mediates a sustained cardioprotective function during cardiac ischemia, it is involved in the inhibition of neutrophil degranulation in neutrophil-mediated tissue injury, it has been implicated in both neuroprotective and neurodegenerative effects, and it may also mediate both cell proliferation and cell death. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
UniProt Comments for ADORA3
ADORA3: Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase. Possible role in reproduction. Belongs to the G-protein coupled receptor 1 family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: GPCR, family 1; Membrane protein, integral; Receptor, GPCR; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 1p13.2

Cellular Component: mast cell granule; integral to plasma membrane; plasma membrane

Molecular Function: adenosine receptor activity, G-protein coupled

Biological Process: positive regulation of phosphoinositide 3-kinase cascade; histamine secretion by mast cell; positive regulation of leukocyte migration; adenylate cyclase activation; response to wounding; positive regulation of mast cell degranulation; positive regulation of calcium-mediated signaling; signal transduction; inflammatory response; adenosine receptor signaling pathway; regulation of heart contraction; positive regulation of inflammatory response
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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