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anti-AK2 antibody :: Rabbit anti-Rat Adenylate Kinase 2 (AK2) Polyclonal Antibody

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Catalog # MBS2064648 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
Unit / Price
Scan QR to view Datasheet
  0.01 mg  /  $125 +1 FREE 8GB USB
  0.02 mg  /  $145 +1 FREE 8GB USB
  0.05 mg  /  $210 +1 FREE 8GB USB
  0.1 mg  /  $280 +1 FREE 8GB USB
  0.2 mg  /  $435 +1 FREE 8GB USB
  1 mg  /  $1,030 +1 FREE 8GB USB
anti-AK2 antibody
Product Name

Adenylate Kinase 2 (AK2), Polyclonal Antibody

Full Product Name

FITC-Linked Polyclonal Antibody to Adenylate Kinase 2 (AK2)

Product Synonym Names
ADK2; Adenylate monophosphate kinase; ATP-AMP transphosphorylase 2; AMP phosphotransferase
Product Gene Name
Matching Pairs
Unconjugated Antibody: Adenylate Kinase 2 (MBS2032171)
FITC Conjugated Antibody: Adenylate Kinase 2 (AK2) (MBS2064648)
Matching Pairs
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
U39945 mRNA
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Rat
Concentration
200ug/ml (lot specific)
Immunogen
AK2 (Leu64~Ser232)
Conjugation
FITC
Unconjugated Antibody
The unconjugated antibody version of this item is also available as catalog #MBS2032171
ISO Certification
Manufactured in an ISO 9001:2008 and ISO 13485:2003 Certified Laboratory.
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.
Other Notes
Small volumes of anti-AK2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-AK2 antibody
Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin/Paraffin, ELISA (ELISA)
NCBI/Uniprot data below describe general gene information for AK2. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
21,636 Da
NCBI Official Full Name
adenylate kinase 2
NCBI Official Synonym Full Names
adenylate kinase 2
NCBI Official Symbol
NCBI Official Synonym Symbols
NCBI Protein Information
adenylate kinase 2, mitochondrial
UniProt Protein Name
Adenylate kinase 2, mitochondrial
UniProt Synonym Protein Names
ATP-AMP transphosphorylase 2
UniProt Gene Name
UniProt Synonym Gene Names
NCBI Summary for AK2
Adenylate kinases are involved in regulating the adenine nucleotide composition within a cell by catalyzing the reversible transfer of phosphate groups among adenine nucleotides. Three isozymes of adenylate kinase, namely 1, 2, and 3, have been identified in vertebrates; this gene encodes isozyme 2. Expression of these isozymes is tissue-specific and developmentally regulated. Isozyme 2 is localized in the mitochondrial intermembrane space and may play a role in apoptosis. Mutations in this gene are the cause of reticular dysgenesis. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 1 and 2.[provided by RefSeq, Nov 2010]
UniProt Comments for AK2
AK2: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in energy metabolism and nucleotide synthesis that is essential for maintenance and cell growth. Plays a key role in hematopoiesis. Defects in AK2 are the cause of reticular dysgenesis (RDYS); also known as aleukocytosis. RDYS is the most severe form of inborn severe combined immunodeficiencies (SCID) and is characterized by absence of granulocytes and almost complete deficiency of lymphocytes in peripheral blood, hypoplasia of the thymus and secondary lymphoid organs, and lack of innate and adaptive humoral and cellular immune functions, leading to fatal septicemia within days after birth. In bone marrow of individuals with reticular dysgenesis, myeloid differentiation is blocked at the promyelocytic stage, whereas erythro- and megakaryocytic maturation is generally normal.In addition, affected newborns have bilateral sensorineural deafness. Defects may be due to its absence in leukocytes and inner ear, in which its absence can not be compensated by AK1. Belongs to the adenylate kinase family. AK2 subfamily. 6 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 2.7.4.3; Kinase, other; Mitochondrial; Nucleotide Metabolism - purine

Chromosomal Location of Human Ortholog: 1p35.1

Cellular Component: mitochondrial intermembrane space

Molecular Function: adenylate kinase activity

Biological Process: nucleobase, nucleoside and nucleotide interconversion

Disease: Reticular Dysgenesis
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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