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anti-CD184 antibody :: Goat anti-Rat CD184 Polyclonal Antibody

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Catalog # MBS224039
Unit / Price
  0.1 mg  /  $455 +1 FREE 8GB USB
Testing Data #1
Product Name

CD184, Polyclonal Antibody

Also Known As

GOAT ANTI HUMAN CD184 (N-TERMINAL)

Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
356
OMIM
162643
Clonality
Polyclonal
Isotype
IgG
Host
Goat
Species Reactivity
Rat
Form/Format
Purified
Purified IgG - liquid
Concentration
IgG concentration 1.0mg/ml (lot specific)
Perservative Stabilisers
0.1% Sodium Azide (NaN3)
0.1% Bovine Serum Albumin
Histology Positive Control Tissue
Spleen
Buffer Solution
Antiserum Preparation
Antiserum to human CD184 (NT) was raised by repeated immunisation of goats with highly purified antigen. Purified IgG was prepared by affinity chromatography.
Target Species
Human
Preparation and Storage
Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
Other Notes
Small volumes of anti-CD184 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-CD184 antibody
Goat anti Human CD184 antibody recognises an epitope within the N-terminal (NT) region of human CD184, otherwise known as CXCR4 (C-X-C chemokine receptor type 4), a transmembrane glycoprotein and member of the G-protein coupled receptor 1 family, ubiquitously expressed in blood and tissue cells, which acts as a specific receptor for the chemokine SDF-1 (Stromal cell-derived factor 1). Interaction of CD184 with SDF-1 mediates the chemotaxis of progenitor and mature blood cells, and is critical for B- lymphopoiesis and myelopoiesis. CD184 is a major co-receptor for infection by T-cell tropic strains of HIV1, and also a primary receptor for some HIV2 isolates. Goat anti Human CD184 antibody is reported as suitable for use in immunofluorescence studies.
Applications Tested/Suitable for anti-CD184 antibody
ELISA (EIA), Immunohistology Paraffin, Western Blot (WB)
Application Notes for anti-CD184 antibody
ELISA: Maximum Dilution: 1/25000;
Immunohistology - Paraffin: Maximum Dilution: 1/150;
Western Blotting: Maximum Dilution: 1/250

Testing Data #1 of anti-CD184 antibody
Paraffin embedded human spleen stained with Goat anti Human CD184 (N-terminal) (MBS224039)
anti-CD184 antibody Testing Data #1 image
NCBI/Uniprot data below describe general gene information for CD184. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
40,221 Da
NCBI Official Full Name
C-X-C chemokine receptor type 4 isoform a
NCBI Official Synonym Full Names
chemokine (C-X-C motif) receptor 4
NCBI Official Symbol
CXCR4  [Similar Products]
NCBI Official Synonym Symbols
FB22; HM89; LAP3; LCR1; NPYR; WHIM; CD184; LAP-3; LESTR; NPY3R; NPYRL; WHIMS; HSY3RR; NPYY3R; D2S201E
  [Similar Products]
NCBI Protein Information
C-X-C chemokine receptor type 4; CD184 antigen; LPS-associated protein 3; SDF-1 receptor; fusin; leukocyte-derived seven transmembrane domain receptor; lipopolysaccharide-associated protein 3; neuropeptide Y receptor Y3; seven transmembrane helix receptor; seven-transmembrane-segment receptor, spleen; stromal cell-derived factor 1 receptor
UniProt Protein Name
C-X-C chemokine receptor type 4
UniProt Synonym Protein Names
FB22; Fusin; HM89; LCR1; Leukocyte-derived seven transmembrane domain receptor; LESTR; Lipopolysaccharide-associated protein 3; LAP-3; LPS-associated protein 3; NPYRL; Stromal cell-derived factor 1 receptor; SDF-1 receptor; CD_antigen: CD184
UniProt Gene Name
CXCR4  [Similar Products]
UniProt Synonym Gene Names
CXC-R4; CXCR-4; LESTR; LAP-3; LPS-associated protein 3; SDF-1 receptor  [Similar Products]
UniProt Entry Name
CXCR4_HUMAN
NCBI Summary for CD184
This gene encodes a CXC chemokine receptor specific for stromal cell-derived factor-1. The protein has 7 transmembrane regions and is located on the cell surface. It acts with the CD4 protein to support HIV entry into cells and is also highly expressed in breast cancer cells. Mutations in this gene have been associated with WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
UniProt Comments for CD184
CXCR4: Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 X4 isolates and as a primary receptor for some HIV-2 isolates. Promotes Env-mediated fusion of the virus. Monomer. Can form dimers. Interacts with CD164. Interacts with HIV-1 surface protein gp120 and Tat. Interacts with ARRB2; the interaction is dependent on the C-terminal phosphorylation of CXCR4 and allows activation of MAPK1 and MAPK3. Interacts with ARRC; the interaction is dependent on the C-terminal phosphorylation of CXCR4 and modulates calcium mobilization. Interacts (via the cytoplasmic C-terminal) with ITCH (via the WW domains I and II); the interaction, enhanced by CXCL12, ubiquitinates CXCR4 and leads to its degradation. Interacts with extracellular ubiquitin. Interacts with human cytomegalovirus/HHV- 5 protein UL78. Expressed in numerous tissues, such as peripheral blood leukocytes, spleen, thymus, spinal cord, heart, placenta, lung, liver, skeletal muscle, kidney, pancreas, cerebellum, cerebral cortex and medulla (in microglia as well as in astrocytes), brain microvascular, coronary artery and umbilical cord endothelial cells. Isoform 1 is predominant in all tissues tested. Belongs to the G-protein coupled receptor 1 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Receptor, GPCR; GPCR, family 1; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 2q21

Cellular Component: growth cone; cell surface; lysosome; early endosome; cytoplasm; cytoplasmic membrane-bound vesicle; leading edge; late endosome; integral to membrane; plasma membrane; intercellular junction; cytoplasmic vesicle; external side of plasma membrane

Molecular Function: G-protein coupled receptor activity; viral receptor activity; ubiquitin binding; protein binding; cytokine binding; ubiquitin protein ligase binding; myosin light chain binding; coreceptor activity; actin binding; C-X-C chemokine receptor activity

Biological Process: entry of virus into host cell; regulation of chemotaxis; neutrophil activation; viral reproduction; activation of MAPK activity; apoptosis; response to virus; neuron migration; calcium-mediated signaling; motor axon guidance; regulation of cell migration; germ cell development; patterning of blood vessels; T cell proliferation; G-protein coupled receptor protein signaling pathway; elevation of cytosolic calcium ion concentration; ameboidal cell migration; germ cell migration; myelin maintenance; response to hypoxia; dendritic cell chemotaxis; entry into host cell; positive regulation of oligodendrocyte differentiation; brain development; inflammatory response

Disease: Whim Syndrome
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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