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anti-CPR antibody :: Rabbit anti-Rat Cytochrome P450 Polyclonal Antibody

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Catalog # MBS2026633 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
Unit / Price
Scan QR to view Datasheet
  0.01 mg  /  $115 +1 FREE 8GB USB
  0.02 mg  /  $135 +1 FREE 8GB USB
  0.05 mg  /  $190 +1 FREE 8GB USB
  0.1 mg  /  $245 +1 FREE 8GB USB
  0.2 mg  /  $365 +1 FREE 8GB USB
  1 mg  /  $870 +1 FREE 8GB USB
Product Name

Cytochrome P450 (CPR), Polyclonal Antibody

Full Product Name

Polyclonal Antibody to Cytochrome P450 Reductase (CPR)

Product Gene Name
Matching Pairs
Matching Pairs
Unconjugated Antibody: Cytochrome P450 (MBS2026633)
APC-CY7 Conjugated Antibody: Cytochrome P450 Reductase (CPR) (MBS2070864)
Matching Pairs
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P00388
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Rat
Specificity
The antibody is a rabbit polyclonal antibody raised against CPR. It has beenselected for its ability to recognize CPR in immunohistochemical staining andwestern blotting.
Purity/Purification
Affinity Chromatography
Form/Format
Liquid
Concentration
200ug/ml (lot specific)
Fragment
CPR (Gly210~Glu578)
Organism Species
Rattus norvegicus (Rat)
Conjugate
No Conjugate
Immunogen
Recombinant CPR (Gly210~Glu578) expressed in E Coli.
Conjugated Antibody
The APC conjugated antibody version of this item is also available as catalog #MBS2070866
Preparation and Storage
Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
ISO Certification
Manufactured in an ISO 9001:2008 and ISO 13485:2003 Certified Laboratory.
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.
Other Notes
Small volumes of anti-CPR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-CPR antibody
Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin/Paraffin, ELISA (EIA)
Application Notes for anti-CPR antibody
Western blotting: 0.2-2ug/mL;1:250-2500
Immunohistochemistry: 5-20ug/mL;1:25-100
Immunocytochemistry: 5-20ug/mL;1:25-100
Optimal working dilutions must be determined by end user.

Western Blot (WB) of anti-CPR antibody
Western Blot: Sample: Mouse Liver lysate; Primary Ab: 1.5ug/ml Rabbit Anti-Rat CPR Antibody Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody
anti-CPR antibody Western Blot (WB) (WB) image
Western Blot (WB) of anti-CPR antibody
Western Blot: Sample: Recombinant protein.
anti-CPR antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-CPR antibody
DAB staining on IHC-P. Samples: Rat Tissue)
anti-CPR antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for CPR. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Related Accession #
Molecular Weight
76,963 Da
NCBI Official Full Name
NADPH--cytochrome P450 reductase
NCBI Official Synonym Full Names
cytochrome p450 oxidoreductase
NCBI Official Symbol
NCBI Official Synonym Symbols
CYPOR
  [Similar Products]
NCBI Protein Information
NADPH--cytochrome P450 reductase
UniProt Protein Name
NADPH--cytochrome P450 reductase
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
CPR; P450R  [Similar Products]
NCBI Summary for CPR
plays a role in electron transport [RGD, Feb 2006]
UniProt Comments for CPR
POR: This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5. Defects in POR are the cause of Antley-Bixler syndrome with genital anomalies and disordered steroidogenesis (ABS1). A disease characterized by the association of Antley-Bixler syndrome with steroidogenesis defects and abnormal genitalia. Antley-Bixler syndrome is characterized by craniosynostosis, radiohumeral synostosis present from the perinatal period, midface hypoplasia, choanal stenosis or atresia, femoral bowing and multiple joint contractures. Defects in POR are the cause of disordered steroidogenesis due to cytochrome P450 oxidoreductase deficiency (DISPORD). A disorder resulting in a rare variant of congenital adrenal hyperplasia, with apparent combined P450C17 and P450C21 deficiency and accumulation of steroid metabolites. Affected girls are born with ambiguous genitalia, but their circulating androgens are low and virilization does not progress. Conversely, affected boys are sometimes born undermasculinized. Boys and girls can present with bone malformations, in some cases resembling the pattern seen in patients with Antley-Bixler syndrome.

Protein type: EC 1.6.2.4; Endoplasmic reticulum; Mitochondrial; Oxidoreductase

Chromosomal Location of Human Ortholog: 12q12

Cellular Component: endoplasmic reticulum membrane; integral component of membrane; intracellular membrane-bound organelle; membrane; mitochondrion

Molecular Function: cytochrome-b5 reductase activity, acting on NAD(P)H; electron transfer activity; enzyme binding; FAD binding; FMN binding; hydrolase activity; iron-cytochrome-c reductase activity; NADP binding; NADPH-hemoprotein reductase activity; nitric oxide dioxygenase activity; oxidoreductase activity

Biological Process: carnitine metabolic process; fatty acid oxidation; flavonoid metabolic process; internal peptidyl-lysine acetylation; negative regulation of apoptosis; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of lipase activity; nitrate catabolic process; nitric oxide catabolic process; positive regulation of cholesterol biosynthetic process; positive regulation of chondrocyte differentiation; positive regulation of monooxygenase activity; positive regulation of smoothened signaling pathway; response to drug; response to nutrient
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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