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anti-GABRG2 antibody :: Rabbit anti-Rat GABA Receptor A, gamma2, Cyto loop Polyclonal Antibody

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Catalog # MBS615572
Unit / Price
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  0.1 mL  /  $775 +1 FREE 8GB USB
anti-GABRG2 antibody
Product Name

GABA Receptor A, gamma2, Cyto loop (GABRG2), Polyclonal Antibody

Full Product Name

GABA Receptor A, gamma2, Cyto loop

Product Synonym Names
Anti -GABA Receptor A, gamma2, Cyto loop
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 5; NC_000005.9 (161494648..161582545). Location: 5q34
OMIM
137164
3D Structure
ModBase 3D Structure for P18507
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Rat
Specificity
GABAA receptor gamma2 subunit. The apparent molecular mass of 44-46kDa in rat brain membrane fractions. Species Crossreactivity: Rat.
Purity/Purification
Affinity Purified
Purified by immunoaffinity chromatography.
Form/Format
Supplied as a liquid n 10 mM Hepes, pH 7.5, with 150 mM sodium chloride, 100ug/ml BSA and 50% glycerol. Approximate concentration is 0.2 mg/mL.
Immunogen
MBP fusion protein from the cytosolic loop of rat GABAA receptor gamma2 subunit.
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and add glycerol (30-50%). Freeze at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Other Notes
Small volumes of anti-GABRG2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-GABRG2 antibody
Applications Tested/Suitable for anti-GABRG2 antibody
Western Blot (WB), Immunoprecipitation (IP)
Application Notes for anti-GABRG2 antibody
Suitable for use in Western Blotting, Immunoprecipitation.
Dilution: Western blot: 1:1000
Immunopreciptation: The antibody will immunoprecipitate ~50% of all GABAA receptors in SDS extracts of rat forebrains (150ul) using 15ug of antibody.
NCBI/Uniprot data below describe general gene information for GABRG2. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
54,162 Da[Similar Products]
NCBI Official Full Name
gamma-aminobutyric acid receptor subunit gamma-2 isoform 1
NCBI Official Synonym Full Names
gamma-aminobutyric acid (GABA) A receptor, gamma 2
NCBI Official Symbol
GABRG2  [Similar Products]
NCBI Official Synonym Symbols
CAE2; ECA2; GEFSP3
  [Similar Products]
NCBI Protein Information
gamma-aminobutyric acid receptor subunit gamma-2; OTTHUMP00000160873; OTTHUMP00000160874; OTTHUMP00000224398; OTTHUMP00000224400; GABA(A) receptor subunit gamma-2
UniProt Protein Name
Gamma-aminobutyric acid receptor subunit gamma-2
UniProt Synonym Protein Names
GABA(A) receptor subunit gamma-2
UniProt Gene Name
GABRG2  [Similar Products]
UniProt Entry Name
GBRG2_HUMAN
NCBI Summary for GABRG2
This gene encodes a gamma-aminobutyric acid (GABA) receptor. GABA is the major inhibitory neurotransmitter in the mammlian brain, where it acts at GABA-A receptors, which are ligand-gated chloride channels. GABA-A receptors are pentameric, consisting of proteins from several subunit classes: alpha, beta, gamma, delta and rho. Mutations in this gene have been associated with epilepsy and febrile seizures. Multiple transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq]
UniProt Comments for GABRG2
GABRG2: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Defects in GABRG2 are the cause of childhood absence epilepsy type 2 (ECA2). ECA2 is a subtype of idiopathic generalized epilepsy (IGE) characterized by an onset at age 6-7 years, frequent absence seizures (several per day) and bilateral, synchronous, symmetric 3-Hz spike waves on EEG. During adolescence, tonic-clonic and myoclonic seizures develop. Some individuals manifest ECA2 occurring in combination with febrile convulsions. Defects in GABRG2 are the cause of familial febrile convulsions type 8 (FEB8). A febrile convulsion is defined as a seizure event in infancy or childhood, usually occurring between 6 months and 6 years of age, associated with fever but without any evidence of intracranial infection or defined pathologic or traumatic cause. Febrile convulsions affect 5-12% of infants and children up to 6 years of age. There is epidemiological evidence that febrile seizures are associated with subsequent afebrile and unprovoked seizures in 2% to 7% of patients. Defects in GABRG2 are the cause of generalized epilepsy with febrile seizures plus type 3 (GEFS+3). Generalized epilepsy with febrile seizures-plus refers to a rare autosomal dominant, familial condition with incomplete penetrance and large intrafamilial variability. Patients display febrile seizures persisting sometimes beyond the age of 6 years and/or a variety of afebrile seizure types. GEFS+ is a disease combining febrile seizures, generalized seizures often precipitated by fever at age 6 years or more, and partial seizures, with a variable degree of severity. Defects in GABRG2 are a cause of severe myoclonic epilepsy in infancy (SMEI); also called Dravet syndrome. SMEI is a rare disorder characterized by generalized tonic, clonic, and tonic-clonic seizures that are initially induced by fever and begin during the first year of life. Later, patients also manifest other seizure types, including absence, myoclonic, and simple and complex partial seizures. Psychomotor development delay is observed around the second year of life. SMEI is considered to be the most severe phenotype within the spectrum of generalized epilepsies with febrile seizures-plus. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRG2 sub-subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Transporter; Transporter, ion channel; Membrane protein, integral; Channel, chloride; Channel, ligand-gated; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 5q34

Cellular Component: postsynaptic membrane; axon; integral to plasma membrane; cytoplasm; plasma membrane; cell junction

Molecular Function: protein binding; chloride channel activity; GABA-A receptor activity; benzodiazepine receptor activity; extracellular ligand-gated ion channel activity

Biological Process: synaptic transmission; transport; adult behavior; synaptic transmission, GABAergic; transmembrane transport; gamma-aminobutyric acid signaling pathway; post-embryonic development

Disease: Epilepsy, Childhood Absence, Susceptibility To, 2; Generalized Epilepsy With Febrile Seizures Plus, Type 3
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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