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anti-NPY1R antibody :: Sheep anti-Rat NEUROPEPTIDE Y RECEPTOR 1 Polyclonal Antibody

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Catalog # MBS221023
Unit / Price
  1 mL  /  $350 +1 FREE 8GB USB
Testing Data #1
Product Name

NEUROPEPTIDE Y RECEPTOR 1 (NPY1R), Polyclonal Antibody

Also Known As

SHEEP ANTI HUMAN NEUROPEPTIDE Y RECEPTOR 1

Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
384
OMIM
162641
3D Structure
ModBase 3D Structure for P25929
Clonality
Polyclonal
Isotype
IgG
Host
Sheep
Species Reactivity
Rat
Specificity
This item is specific for human neuropeptide Y receptor 1. Neuropeptide Y receptors are a class of G-protein coupled receptors which are activated by the closely related peptide hormones neuropeptide Y, peptide YY and pancreatic polypeptide. These receptors are involved in control of a diverse set of behavioral processes including appetite, circadian rhythm, and anxiety.
Form/Format
Purified
Purified IgG - liquid
Concentration
IgG concentration 5.0 mg/ml (lot specific)
Perservative Stabilisers
0.09% Sodium Azide (NaN3)
Preparation
Immunogen
A synthetic peptide corresponding to amino acids 365 - 378 of human NPY1R, conjugated to KLH.Peptide sequence: KQASPVAFKKINNN
Buffer Solution
Target Species
Human
Preparation and Storage
Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
Other Notes
Small volumes of anti-NPY1R antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-NPY1R antibody
MBS221023 is specific for human neuropeptide Y receptor 1. Neuropeptide Y receptors are a class of G-protein coupled receptors which are activated by the closely related peptide hormones neuropeptide Y, peptide YY and pancreatic polypeptide. These receptors are involved in control of a diverse set of behavioral processes including appetite, circadian rhythm, and anxiety.
Applications Tested/Suitable for anti-NPY1R antibody
ELISA (EIA), Immunohistology Paraffin*, Western Blot (WB)
Application Notes for anti-NPY1R antibody
Western Blot: This item detects a band of approximately 55 kDa in human brain.
Immunohistology - Paraffin: Application Note: This product requires antigen retrieval using heat treatment prior to staining of paraffin sections. Sodium citrate buffer pH 6.0 is recommended for this purpose.
Western Blotting: Minimum Dilution: 1/100; Maximum Dilution: 1/1000

Testing Data #1 of anti-NPY1R antibody
Human brain lysate probed with Sheep anti Human Neuropeptide Y Receptor 1 (MBS221023)
anti-NPY1R antibody Testing Data #1 image
NCBI/Uniprot data below describe general gene information for NPY1R. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
44,392 Da[Similar Products]
NCBI Official Full Name
neuropeptide Y receptor type 1
NCBI Official Synonym Full Names
neuropeptide Y receptor Y1
NCBI Official Symbol
NPY1R  [Similar Products]
NCBI Official Synonym Symbols
NPYR; NPY1-R
  [Similar Products]
NCBI Protein Information
neuropeptide Y receptor type 1
UniProt Protein Name
Neuropeptide Y receptor type 1
Protein Family
UniProt Gene Name
NPY1R  [Similar Products]
UniProt Synonym Gene Names
NPYR; NPYY1; NPY1-R  [Similar Products]
UniProt Entry Name
NPY1R_HUMAN
NCBI Summary for NPY1R
This gene belongs to the G-protein-coupled receptor superfamily. The encoded transmembrane protein mediates the function of neuropeptide Y (NPY), a neurotransmitter, and peptide YY (PYY), a gastrointestinal hormone. The encoded receptor undergoes fast agonist-induced internalization through clathrin-coated pits and is subsequently recycled back to the cell membrane. Activation of Y1 receptors may result in mobilization of intracellular calcium and inhibition of adenylate cyclase activity. [provided by RefSeq, Aug 2013]
UniProt Comments for NPY1R
NPY1R: Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is NPY > [Pro-34] PYY, PYY and [Leu-31, Pro-34] NPY > NPY (2-36) > [Ile-31, Gln-34] PP and PYY (3-36) > PP > NPY free acid. Belongs to the G-protein coupled receptor 1 family.

Protein type: GPCR, family 1; Membrane protein, multi-pass; Receptor, GPCR; Membrane protein, integral

Chromosomal Location of Human Ortholog: 4q31.3-q32

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: peptide YY receptor activity; protein binding; pancreatic polypeptide receptor activity; neuropeptide Y receptor activity

Biological Process: G-protein signaling, coupled to cyclic nucleotide second messenger; neuropeptide signaling pathway; regulation of blood pressure; regulation of multicellular organism growth; glucose metabolic process; locomotory behavior; feeding behavior; G-protein signaling, adenylate cyclase inhibiting pathway; sensory perception of pain
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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