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anti-PVR antibody :: Rabbit anti-Rat Poliovirus Receptor Polyclonal Antibody

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Catalog # MBS2027307 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
Unit / Price
  0.01 mg  /  $110 +1 FREE 8GB USB
  0.02 mg  /  $130 +1 FREE 8GB USB
  0.05 mg  /  $185 +1 FREE 8GB USB
  0.1 mg  /  $230 +1 FREE 8GB USB
  0.2 mg  /  $345 +1 FREE 8GB USB
  1 mg  /  $825 +1 FREE 8GB USB
Product Name

Poliovirus Receptor (PVR), Polyclonal Antibody

Popular Item
Also Known As

Polyclonal Antibody to Poliovirus Receptor (PVR)

Product Gene Name
Matching Pairs
Matching Pairs
Unconjugated Antibody: Poliovirus Receptor (MBS2027307)
APC-CY7 Conjugated Antibody: Poliovirus Receptor (PVR) (MBS2056430)
Matching Pairs
Unconjugated Antibody: Poliovirus Receptor (MBS2027307)
PE Conjugated Antibody: Poliovirus Receptor (PVR) (MBS2056431)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
412
3D Structure
ModBase 3D Structure for Q5U334
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Rat
Specificity
The antibody is a rabbit polyclonal antibody raised against PVR. It has been selected for its ability to recognize PVR in immunohistochemical staining and western blotting.
Purity/Purification
Affinity Chromatography
Form/Format
Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Concentration
200ug/ml (lot specific)
Preparation and Storage
Store at 4 degree C for frequent use. Stored at -20 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
Other Notes
Small volumes of anti-PVR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-PVR antibody
Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin/Paraffin, ELISA (EIA)
Application Notes for anti-PVR antibody
Western blotting: 1:50-400
Immunocytochemistry in formalin fixed cells: 1:50-500
Immunohistochemistry in formalin fixed frozen section: 1:50-500
Immunohistochemistry in paraffin section: 1:10-100
Enzyme-linked Immunosorbent Assay: 1:100-200
Optimal working dilutions must be determined by end user.

Western Blot (WB) of anti-PVR antibody
Western Blot: Sample: Rat Heart lysate; Primary Ab: 2ug/ml Rabbit Anti-Rat PVR Antibody Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody
anti-PVR antibody Western Blot (WB) (WB) image
Western Blot (WB) of anti-PVR antibody
Western Blot: Sample: Recombinant protein.
anti-PVR antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-PVR antibody
DAB staining on fromalin fixed paraffin- embedded Kidney tissue)
anti-PVR antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for PVR. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
Molecular Weight
44,512 Da
NCBI Official Full Name
poliovirus receptor
NCBI Official Synonym Full Names
poliovirus receptor
NCBI Official Symbol
NCBI Official Synonym Symbols
Taa1; Tage4
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NCBI Protein Information
poliovirus receptor
UniProt Protein Name
Poliovirus receptor
UniProt Synonym Protein Names
Poliovirus receptor
Protein Family
UniProt Gene Name
NCBI Summary for PVR
may act as a receptor to mediate entry of some viruses [RGD, Feb 2006]
UniProt Comments for PVR
PVR: Mediates NK cell adhesion and triggers NK cell effector functions. Binds two different NK cell receptors: CD96 and CD226. These interactions accumulates at the cell-cell contact site, leading to the formation of a mature immunological synapse between NK cell and target cell. This may trigger adhesion and secretion of lytic granules and IFN-gamma and activate cytoxicity of activated NK cells. May also promote NK cell-target cell modular exchange, and PVR transfer to the NK cell. This transfer is more important in some tumor cells expressing a lot of PVR, and may trigger fratricide NK cell activation, providing tumors with a mechanism of immunoevasion. Plays a role in mediating tumor cell invasion and migration. Serves as a receptor for poliovirus attachment to target cells. May play a role in axonal transport of poliovirus, by targeting virion-PVR-containing endocytic vesicles to the microtubular network through interaction with DYNLT1. This interaction would drive the virus-containing vesicle to the axonal retrograde transport. Belongs to the nectin family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Immunoglobulin superfamily; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.

Chromosomal Location of Human Ortholog: 1q21

Cellular Component: cell surface; focal adhesion; integral component of membrane; plasma membrane

Molecular Function: cell adhesion molecule binding; dynein light chain binding; viral receptor activity

Biological Process: cell migration; entry of virus into host cell; positive regulation of natural killer cell mediated cytotoxicity; positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target; susceptibility to natural killer cell mediated cytotoxicity
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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