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anti-RAMP1 antibody :: Goat anti-Rat RAMP1 Polyclonal Antibody

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Catalog # MBS622973
Unit / Price
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  0.1 mg  /  $560 +1 FREE 8GB USB
anti-RAMP1 antibody
Product Name

RAMP1, Polyclonal Antibody

Full Product Name

RAMP1 (Receptor Activity Modifying Protein1, Receptor Activity Modifying Protein 1 [Precursor], Receptor (G Protein-coupled) Activity Modifying Protein 1, Calcitonin Receptor-like Receptor Activity Modifying Protein 1, CRLR Activity Modifying Protein 1)

Product Synonym Names
Anti -RAMP1 (Receptor Activity Modifying Protein1, Receptor Activity Modifying Protein 1 [Precursor], Receptor (G Protein-coupled) Activity Modifying Protein 1, Calcitonin Receptor-like Receptor Activity Modifying Protein 1, CRLR Activity Modifying Protein 1)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 2; NC_000002.11 (238768187..238820756). Location: 2q36-q37.1
OMIM
605153
3D Structure
ModBase 3D Structure for O60894
Clonality
Polyclonal
Isotype
IgG
Host
Goat
Species Reactivity
Rat
Specificity
Recognizes rat Ramp1. Sequence homology: human, mouse.
Purity/Purification
Affinity Purified
Purified by affinity chromatography.
Form/Format
Supplied as a liquid in Tris saline, 0.02% sodium azide, pH7.3, 0.5% BSA.
Immunogen
Synthetic peptide corresponding to C-DYQSKRTEGIV, from the C-Terminus of rat Ramp1 (NP_058590.1; NP_848488.2).
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Other Notes
Small volumes of anti-RAMP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-RAMP1 antibody
RAMPS may be involved in the transport of CRLR to the plasma membrane. RAMP1 (human, mouse, rat 148 aa) presents the CRLR receptor as a glycoprotein that function as CGRP receptor. RAMP1 is expressed in many tissues, including the uterus, bladder, brain, pancreas, and GI tract. CRLR and RAMP1 are not co-expressed in all tissues suggesting that their co-expression may define which cells express functional CGRP receptors. RAMP2 (human 175 aa; rat 182 aa, and mouse 189 aa)-transported receptors are core-glycosylated and function as ADM receptor. It is expressed in the lung, breast, immune system and fetal tissues. RAMP3 is most abundant in the kidney and lung.
Applications Tested/Suitable for anti-RAMP1 antibody
Western Blot (WB)
Application Notes for anti-RAMP1 antibody
Suitable for use in ELISA and Western Blot.
Dilution: ELISA: 1:64,000
NCBI/Uniprot data below describe general gene information for RAMP1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
16,988 Da[Similar Products]
NCBI Official Full Name
receptor activity-modifying protein 1
NCBI Official Synonym Full Names
receptor (G protein-coupled) activity modifying protein 1
NCBI Official Symbol
RAMP1  [Similar Products]
NCBI Official Synonym Symbols
RAMP1
  [Similar Products]
NCBI Protein Information
receptor activity-modifying protein 1; OTTHUMP00000164475; CRLR activity-modifying protein 1; receptor activity modifying protein 1; receptor (calcitonin) activity modifying protein 1; calcitonin receptor-like receptor activity modifying protein 1; calcitonin-receptor-like receptor activity-modifying protein 1
UniProt Protein Name
Receptor activity-modifying protein 1
UniProt Synonym Protein Names
Calcitonin-receptor-like receptor activity-modifying protein 1
UniProt Gene Name
RAMP1  [Similar Products]
UniProt Entry Name
RAMP1_HUMAN
NCBI Summary for RAMP1
The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP1) protein, CRLR functions as a CGRP receptor. The RAMP1 protein is involved in the terminal glycosylation, maturation, and presentation of the CGRP receptor to the cell surface. [provided by RefSeq]
UniProt Comments for RAMP1
RAMP1: Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as a receptor for calcitonin-gene-related peptide (CGRP) together with CALCRL. Belongs to the RAMP family.

Protein type: Receptor, GPCR; Membrane protein, integral

Chromosomal Location of Human Ortholog: 2q36-q37.1

Cellular Component: extracellular space; cell surface; integral to plasma membrane; plasma membrane; receptor complex

Molecular Function: protein binding; calcitonin receptor binding; coreceptor activity; receptor activity; protein transporter activity; calcitonin receptor activity

Biological Process: G-protein coupled receptor protein signaling pathway; intracellular protein transport; protein transport; positive regulation of protein amino acid glycosylation; receptor internalization; calcium ion transport; positive regulation of cAMP biosynthetic process; angiogenesis; regulation of G-protein coupled receptor protein signaling pathway
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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