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anti-Sort1 antibody :: Rabbit anti-Rat Sortilin Polyclonal Antibody

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Catalog # MBS1492585
Unit / Price
  0.05 mg  /  $160 +1 FREE 8GB USB
  0.1 mg  /  $235 +1 FREE 8GB USB
anti-Sort1 antibody
Product Name

Sortilin (Sort1), Polyclonal Antibody

Also Known As

Rabbit anti-rat Sortilin polyclonal Antibody, HRP conjugated

Product Synonym Names
Glycoprotein 110; Neurotensin receptor 3; Sort1
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
825
3D Structure
ModBase 3D Structure for O54861
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Rat
Purity/Purification
Caprylic Acid Ammonium Sulfate Precipitation Purified
Storage Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Conjugate
HRP
Immunogen
Recombinant rat Sortilin protein(610-754aa)
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-Sort1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-Sort1 antibody
Functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). Also required for protein transport from the Golgi apparatus to the endosomes. Promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB). Also acts as a receptor for neurotensin. May promote mineralization of the extracellular matrix during osteogenic differentiation by scavenging extracellular LPL. Probably required in adipocytes for the formation of specialized storage vesicles containing the glucose transporter SLC2A4/GLUT4 (GLUT4 storage vesicles, or GSVs). These vesicles provide a stable pool of SLC2A4 and confer increased responsiveness to insulin. May also mediate transport from the endoplasmic reticulum to the Golgi.
Applications Tested/Suitable for anti-Sort1 antibody
ELISA (EIA)
NCBI/Uniprot data below describe general gene information for Sort1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
91,169 Da[Similar Products]
NCBI Official Full Name
sortilin
NCBI Official Synonym Full Names
sortilin 1
NCBI Official Symbol
Sort1  [Similar Products]
NCBI Official Synonym Symbols
Nt3; Nts3
  [Similar Products]
NCBI Protein Information
sortilin
UniProt Protein Name
Sortilin
UniProt Synonym Protein Names
Glycoprotein 110; Gp110; Neurotensin receptor 3; NTR3
Protein Family
UniProt Gene Name
Sort1  [Similar Products]
UniProt Synonym Gene Names
Gp110; NTR3  [Similar Products]
UniProt Entry Name
SORT_RAT
NCBI Summary for Sort1
may be involved in sorting lumenal proteins in the trans-Golgi [RGD, Feb 2006]
UniProt Comments for Sort1
SORT1: Functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). Also required for protein transport from the Golgi apparatus to the endosomes. Promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB). Also acts as a receptor for neurotensin. May promote mineralization of the extracellular matrix during osteogenic differentiation by scavenging extracellular LPL. Probably required in adipocytes for the formation of specialized storage vesicles containing the glucose transporter SLC2A4/GLUT4 (GLUT4 storage vesicles, or GSVs). These vesicles provide a stable pool of SLC2A4 and confer increased responsiveness to insulin. May also mediate transport from the endoplasmic reticulum to the Golgi. A common polymorphism located in a non-coding region between CELSR2 and PSRC1 alters a CEBP transcription factor binding site and is responsible for changes in hepatic expression of SORT1. Altered SORT1 expression in liver affects low density lipoprotein cholesterol levels in plasma and is associated with susceptibility to myocardial infarction. Belongs to the VPS10-related sortilin family. SORT1 subfamily.

Protein type: Receptor, misc.; Membrane protein, integral

Cellular Component: cell soma; cell surface; clathrin-coated vesicle; coated pit; cytoplasmic membrane-bound vesicle; dendrite; early endosome; endoplasmic reticulum membrane; endosome membrane; Golgi apparatus; integral to membrane; intracellular membrane-bound organelle; lysosomal membrane; nuclear membrane; perinuclear region of cytoplasm; plasma membrane; trans-Golgi network transport vesicle

Molecular Function: enzyme binding; nerve growth factor binding; nerve growth factor receptor activity; neurotensin receptor activity, G-protein coupled; neurotensin receptor activity, non-G-protein coupled

Biological Process: endocytosis; endosome to lysosome transport; endosome transport via multivesicular body sorting pathway; G-protein coupled receptor protein signaling pathway; glucose import; Golgi to endosome transport; induction of apoptosis via death domain receptors; intracellular protein transport; multicellular organismal development; myotube differentiation; negative regulation of fat cell differentiation; negative regulation of lipoprotein lipase activity; nerve growth factor receptor signaling pathway; neuropeptide signaling pathway; ossification; plasma membrane to endosome transport; regulation of gene expression; response to insulin stimulus; vesicle organization and biogenesis
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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