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anti-AVPR2 antibody :: Rabbit anti-Rat Vasopressin Receptor, Arg, V2 Polyclonal Antibody

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Catalog # MBS618067
Unit / Price
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  0.1 mL  /  $720 +1 FREE 8GB USB
anti-AVPR2 antibody
Product Name

Vasopressin Receptor, Arg, V2 (AVPR2), Polyclonal Antibody

Full Product Name

Vasopressin Receptor, Arg, V2 (AVP-V2)

Product Synonym Names
Anti -Vasopressin Receptor, Arg, V2 (AVP-V2)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: X; NC_000023.10 (153167985..153172620). Location: Xq28
OMIM
300538
3D Structure
ModBase 3D Structure for P30518
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Rat
Specificity
Recognizes rat Arginine Vasopressin Receptor V2 (AVR-V2). The immunogen shows no significant sequence homology with AVR-V1a or AVR-V1b. Species homology: 95% mouse,
Purity/Purification
Serum
Serum
Form/Format
Supplied as a lyophilized powder from PBS, 0.05% sodium azide.
Immunogen
A 21 AA peptide sequence from rat AVP-V2 receptor. (1). This peptide is predicted to be cytoplasmic. The peptide was synthesized as Cysteine at the NH2-terminus and coupled to KLH
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage, store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Other Notes
Small volumes of anti-AVPR2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-AVPR2 antibody
Applications Tested/Suitable for anti-AVPR2 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-AVPR2 antibody
Suitable for use in ELISA and Western Blot.
Dilution: Western Blot: 1:1000-1:5000
ELISA: 1:10,000-1:50,000
NCBI/Uniprot data below describe general gene information for AVPR2. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
40,279 Da[Similar Products]
NCBI Official Full Name
Vasopressin V2 receptor
NCBI Official Synonym Full Names
arginine vasopressin receptor 2
NCBI Official Symbol
AVPR2  [Similar Products]
NCBI Official Synonym Symbols
DI1; DIR; NDI; V2R; ADHR; DIR3; MGC126533; MGC138386
  [Similar Products]
NCBI Protein Information
vasopressin V2 receptor; AVPR V2; OTTHUMP00000026011; OTTHUMP00000026013; OTTHUMP00000198719; antidiuretic hormone receptor; renal-type arginine vasopressin receptor
UniProt Protein Name
Vasopressin V2 receptor
UniProt Synonym Protein Names
AVPR V2; Antidiuretic hormone receptor; Renal-type arginine vasopressin receptor
Protein Family
UniProt Gene Name
AVPR2  [Similar Products]
UniProt Synonym Gene Names
ADHR; DIR; DIR3; V2R  [Similar Products]
UniProt Entry Name
V2R_HUMAN
NCBI Summary for AVPR2
This gene encodes the vasopressin receptor, type 2, also known as the V2 receptor, which belongs to the seven-transmembrane-domain G protein-coupled receptor (GPCR) superfamily, and couples to Gs thus stimulating adenylate cyclase. The subfamily that includes the V2 receptor, the V1a and V1b vasopressin receptors, the oxytocin receptor, and isotocin and mesotocin receptors in non-mammals, is well conserved, though several members signal via other G proteins. All bind similar cyclic nonapeptide hormones. The V2 receptor is expressed in the kidney tubule, predominantly in the distal convoluted tubule and collecting ducts, where its primary property is to respond to the pituitary hormone arginine vasopressin (AVP) by stimulating mechanisms that concentrate the urine and maintain water homeostasis in the organism. When the function of this gene is lost, the disease Nephrogenic Diabetes Insipidus (NDI) results. The V2 receptor is also expressed outside the kidney although its tissue localization is uncertain. When these 'extrarenal receptors' are stimulated by infusion of a V2 selective agonist (dDAVP), a variety of clotting factors are released into the bloodstream. The physiologic importance of this property is not known - its absence does not appear to be detrimental in NDI patients. The gene expression has also been described in fetal lung tissue and lung cancer associated with alternative splicing. [provided by RefSeq]
UniProt Comments for AVPR2
AVPR2: Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Involved in renal water reabsorption. Defects in AVPR2 are the cause of nephrogenic syndrome of inappropriate antidiuresis (NSIAD). This disorder is characterized by an inability to excrete a free water load, with inappropriately concentrated urine and resultant hyponatremia, hypoosmolarity, and natriuresis. Defects in AVPR2 are the cause of diabetes insipidus nephrogenic X-linked (XNDI); also known as diabetes insipidus nephrogenic type 1. XNDI is caused by the inability of the renal collecting ducts to absorb water in response to arginine vasopressin. It is characterized by excessive water drinking (polydypsia), excessive urine excretion (polyuria), persistent hypotonic urine, and hypokalemia. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; Transporter, aquaporin family; GPCR, family 1; Receptor, GPCR; Transporter; Membrane protein, integral

Chromosomal Location of Human Ortholog: Xq28

Cellular Component: Golgi apparatus; endoplasmic reticulum; integral to plasma membrane; integral to membrane; plasma membrane; endosome

Molecular Function: protein binding; peptide binding; vasopressin receptor activity

Biological Process: I-kappaB kinase/NF-kappaB cascade; water transport; adenylate cyclase activation; positive regulation of systemic arterial blood pressure; excretion; cellular response to hormone stimulus; G-protein signaling, coupled to cAMP nucleotide second messenger; telencephalon development; regulation of systemic arterial blood pressure by vasopressin; hemostasis; positive regulation of protein ubiquitination; response to cytokine stimulus; positive regulation of cell proliferation; positive regulation of vasoconstriction; interferon-gamma production; renal water homeostasis; transmembrane transport

Disease: Nephrogenic Syndrome Of Inappropriate Antidiuresis; Diabetes Insipidus, Nephrogenic, X-linked
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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Products associated with anti-AVPR2 antibody
 Reference Product  PubMed Publications
 AVP antibody  >33 publications with AVPR2 and AVP
Organs/Tissues associated with anti-AVPR2 antibody
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >1 publications with AVPR2 and Lung
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