NP_006735.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
retinol-binding protein 4
NCBI Official Synonym Full Names
retinol binding protein 4
NCBI Protein Information
retinol-binding protein 4
UniProt Protein Name
Retinol-binding protein 4
UniProt Synonym Protein Names
Plasma retinol-binding protein; PRBP; RBP
UniProt Synonym Gene Names
UniProt Entry Name
RET4_HUMAN
UniProt Comments for RBP4
RBP4: Delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin, this prevents its loss by filtration through the kidney glomeruli. Defects in RBP4 are a cause of retinol-binding protein deficiency (RBP deficiency). This condition causes night vision problems. It produces a typical 'fundus xerophthalmicus', featuring a progressed atrophy of the retinal pigment epithelium. Belongs to the calycin superfamily. Lipocalin family.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 10q23.33
Cellular Component: cytosol; extracellular region; extracellular space
Molecular Function: protein binding; retinol binding
Biological Process: cardiac muscle development; embryonic organ morphogenesis; embryonic retina morphogenesis in camera-type eye; embryonic skeletal development; eye development; female genitalia morphogenesis; gluconeogenesis; glucose homeostasis; heart development; lung development; maintenance of gastrointestinal epithelium; negative regulation of cardiac muscle cell proliferation; positive regulation of immunoglobulin secretion; positive regulation of insulin secretion; response to retinoic acid; retinoid metabolic process; retinol metabolic process; urinary bladder development; uterus development; vagina development
Disease: Microphthalmia, Isolated, With Coloboma 10; Retinal Dystrophy, Iris Coloboma, And Comedogenic Acne Syndrome
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Products associated with anti-RBP4 antibody
Pathways associated with anti-RBP4 antibody
Diseases associated with anti-RBP4 antibody
Organs/Tissues associated with anti-RBP4 antibody
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