NP_062042.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
alpha-synuclein
NCBI Official Synonym Full Names
synuclein, alpha (non A4 component of amyloid precursor)
NCBI Protein Information
alpha-synuclein
UniProt Protein Name
Alpha-synuclein
UniProt Entry Name
SYUA_RAT
NCBI Summary for SNCA
may play a role in regulation of synaptic vesicle biogenesis and organization; may be involved in neurotransmission [RGD, Feb 2006]
UniProt Comments for SNCA
Function: May be involved in the regulation of dopamine release and transport.
Subunit structure: Interacts with UCHL1. Ref.7
Subcellular location: Cytoplasm
By similarity.
Tissue specificity: Found only in brain (hippocampus, brainstem and cortex). Specifically expressed in neuronal cell bodies and synapses.
Post-translational modification: Phosphorylated, predominantly on serine residues. Phosphorylated on Tyr-125 upon osmotic stress
By similarity.Ubiquitinated. The predominant conjugate is the diubiquitinated form. Ref.7Acetylation at Met-1 seems to be important for proper folding and native oligomeric structure
By similarity.
Sequence similarities: Belongs to the synuclein family.
Product References and Citations for anti-SNCA antibody
• Okochi M, Walter J, Koyama A, Nakajo S, Baba M, Iwatsubo T, Meijer L, Kahle PJ, Haass C (2000) Constitutive phosphorylation of the Parkinson's disease associated alphasynuclein. J Biol Chem Jan 7;275(1): 390-7. • Neumann M, Kahle PJ, Giasson BI, Ozmen L, Borroni E, Spooren W, Muller V, Odoy S, Fujiwara H, Hasegawa M, Iwatsubo T, Trojanowski JQ, Kretzschmar HA, Haass C (2002) Misfolded proteinase k resistant hyperphosphorylated alpha-synuclein in aged transgenic mice with locomotor deterioration and in human alpha synucleinopathies. J Clin Invest Nov; 110(10):1403-5. • Smith WW, Margolis RL, Li X, Troncoso JC, Lee MK, Dawson VL, Dawson TM, Iwatsubo T, Ross CA (2005) Alpha-synuclein phosphorylation enhances eosinophilic cytoplasmic inclusion formation in SH-SY5Y Cells. J Neurosci June 8; 25(23):5544-5552. • Masliah E, Rockenstein E, Adame A, Alford M, Crews L, Hashimoto M, Suebert P, Lee M, Goldstein J, Chilcote T, Games D, Schenk D (2005) Effects of alpha-synuclein immunization in a mouse model of Parkinson's disease. Neuron Jun 16;46(6):857-868.
Research Articles on SNCA
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Products associated with anti-SNCA antibody
Pathways associated with anti-SNCA antibody
Diseases associated with anti-SNCA antibody
Organs/Tissues associated with anti-SNCA antibody
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