AAB41498.1
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
~240 kDa
NCBI Official Full Name
alpha II spectrin
NCBI Official Synonym Full Names
spectrin, alpha, non-erythrocytic 1
NCBI Protein Information
spectrin alpha chain, non-erythrocytic 1; alpha-fodrin; alpha-II spectrin; fodrin alpha chain; spectrin, non-erythroid alpha chain; spectrin, non-erythroid alpha subunit
UniProt Protein Name
Spectrin alpha chain, non-erythrocytic 1
UniProt Synonym Protein Names
Alpha-II spectrin; Fodrin alpha chain; Spectrin, non-erythroid alpha subunit
UniProt Synonym Gene Names
UniProt Entry Name
SPTN1_HUMAN
NCBI Summary for SPTAN1
Spectrins are a family of filamentous cytoskeletal proteins that function as essential scaffold proteins that stabilize the plasma membrane and organize intracellular organelles. Spectrins are composed of alpha and beta dimers that associate to form tetramers linked in a head-to-head arrangement. This gene encodes an alpha spectrin that is specifically expressed in nonerythrocytic cells. The encoded protein has been implicated in other cellular functions including DNA repair and cell cycle regulation. Mutations in this gene are the cause of early infantile epileptic encephalopathy-5. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Sep 2010]
UniProt Comments for SPTAN1
Function: Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane.
Subunit structure: Like erythrocyte spectrin, the spectrin-like proteins are capable of forming dimers which can further associate to tetramers. Interacts (via C-terminal spectrin repeats) with TRPC4. Interacts with CALM and EMD. Interacts with isoform 1 of ACP1. Identified in a complex with ACTN4, CASK, IQGAP1, MAGI2, NPHS1 and SPTBN1. Interacts with SHANK3 (via ANK repeats). Ref.14 Ref.15 Ref.17
Subcellular location: Cytoplasm › cytoskeleton. Cytoplasm › cell cortex. Note: Expressed along the cell membrane in podocytes and presumptive tubule cells during glomerulogenesis and is expressed along lateral cell margins in tubule cells
By similarity.
Post-translational modification: Phosphorylation of Tyr-1176 decreases sensitivity to cleavage by calpain in vitro
By similarity.
Involvement in disease: Epileptic encephalopathy, early infantile, 5 (EIEE5) [MIM:613477]: A disorder characterized by seizures associated with hypsarrhythmia, profound mental retardation with lack of visual attention and speech development, as well as spastic quadriplegia.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.28
Sequence similarities: Belongs to the spectrin family.Contains 3 EF-hand domains.Contains 1 SH3 domain.Contains 23 spectrin repeats.
Sequence caution: The sequence BAD93097.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
Product References and Citations for anti-SPTAN1 antibody
• Bennett V & Baines AJ.(2001) Spectrin and ankyrin-based pathways: metazoan inventions for integrating cells into tissues. Physiol Rev. 81:1353-92. • Eber S & Lux SE. (2004) Hereditary spherocytosis--defects in proteins that connect the membrane skeleton to the lipid bilayer. Semin Hematol 41:118-41.
Research Articles on SPTAN1
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Pathways associated with anti-SPTAN1 antibody
Diseases associated with anti-SPTAN1 antibody
Organs/Tissues associated with anti-SPTAN1 antibody
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