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anti-ESR2 antibody :: Rabbit anti-Human Estrogen Receptor-beta Polycolonal Antibody

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Catalog # MBS9416656
Unit / Price
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  0.05 mL  /  $200 +1 FREE 8GB USB
  0.1 mL  /  $255 +1 FREE 8GB USB
Western Blot (WB)
Product Name

Estrogen Receptor-beta (ESR2), Polycolonal Antibody

Full Product Name

Estrogen Receptor-beta (Phospho-Ser87) Antibody

Product Synonym Names
ESR2; ESTRB; ER Beta; ERbeta; ER-BETA; ESR-BETA; ESRB; Estrogen receptor 2 (ER beta); NR3A2; Estrogen receptor beta; Estrogen receptor beta 4
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
AB006590 mRNA
3D Structure
ModBase 3D Structure for Q92731
Clonality
Polycolonal
Host
Rabbit
Species Reactivity
Human
Specificity
Estrogen Receptor-b (Phospho-Ser87) Antibody detects endogenous levels of Estrogen Receptor-b only when phosphorylated at Ser87
Purity/Purification
Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
Form/Format
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1 mg/ml (lot specific)
Immunogen
A synthesized peptide derived from human Estrogen Receptor-b (Phospho-Ser87)
Immunogen Type
Peptide
Modification
Phospho-Ser87
Preparation and Storage
Store at -20 degree C
Other Notes
Small volumes of anti-ESR2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-ESR2 antibody
Applications Tested/Suitable for anti-ESR2 antibody
Western Blot (WB)
Application Notes for anti-ESR2 antibody
Western Blot: 1:1000

Western Blot (WB) of anti-ESR2 antibody
Western blot analysis Estrogen Receptor-b (Phospho-Ser87) using forskolin treated HeLa whole cell lysates
anti-ESR2 antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for ESR2. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
53,209 Da[Similar Products]
NCBI Official Full Name
estrogen receptor beta isoform 2
NCBI Official Synonym Full Names
estrogen receptor 2
NCBI Official Symbol
NCBI Official Synonym Symbols
Erb; ESRB; ESTRB; NR3A2; ER-BETA; ESR-BETA
  [Similar Products]
NCBI Protein Information
estrogen receptor beta
UniProt Protein Name
Estrogen receptor beta
UniProt Synonym Protein Names
Nuclear receptor subfamily 3 group A member 2
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
ESTRB; NR3A2; ER-beta  [Similar Products]
UniProt Entry Name
ESR2_HUMAN
NCBI Summary for ESR2
This gene encodes a member of the family of estrogen receptors and superfamily of nuclear receptor transcription factors. The gene product contains an N-terminal DNA binding domain and C-terminal ligand binding domain and is localized to the nucleus, cytoplasm, and mitochondria. Upon binding to 17beta-estradiol or related ligands, the encoded protein forms homo- or hetero-dimers that interact with specific DNA sequences to activate transcription. Some isoforms dominantly inhibit the activity of other estrogen receptor family members. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been fully characterized. [provided by RefSeq, Jul 2008]
UniProt Comments for ESR2
ER-beta: a nuclear hormone receptor and transcription factor. Binds and activated by estrogen. Regulates gene expression and affects cellular proliferation and differentiation in target tissues. Binds estrogens with an affinity similar to that of ER-alpha, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. Eight alternatively-spliced isoforms have been described. Isoform beta-cx lacks ligand binding ability and has no or only very low ERE binding activity resulting in the loss of ligand-dependent transactivation ability.

Protein type: DNA-binding; Nuclear receptor

Chromosomal Location of Human Ortholog: 14q23.2

Cellular Component: mitochondrion; nucleoplasm; nucleus

Molecular Function: DNA binding; enzyme binding; estrogen receptor activity; estrogen response element binding; protein binding; steroid binding; steroid hormone receptor activity; transcription coactivator activity; transcription factor activity

Biological Process: cell-cell signaling; estrogen receptor signaling pathway; negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription factor activity; positive regulation of transcription, DNA-dependent; regulation of transcription, DNA-dependent; signal transduction; transcription initiation from RNA polymerase II promoter
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Organs/Tissues associated with anti-ESR2 antibody
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