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anti-AR antibody :: Rabbit Androgen Receptor Polycolonal Antibody

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Catalog # MBS9416655
Unit / Price
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  0.05 mL  /  $200 +1 FREE 8GB USB
  0.1 mL  /  $255 +1 FREE 8GB USB
Western Blot (WB)
Product Name

Androgen Receptor (AR), Polycolonal Antibody

Popular Item
Full Product Name

Androgen Receptor (Phospho-Tyr534) Antibody

Product Synonym Names
AR; Androgen receptor; Dihydrotestosterone receptor; DHTR; AIS; KD; NR3C4; HUMARA; SBMA; TFM; SMAX1; HYSP1
Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
M20132 mRNA
3D Structure
ModBase 3D Structure for P10275
Clonality
Polycolonal
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Specificity
Androgen Receptor (Phospho-Tyr534) Antibody detects endogenous levels of Androgen Receptor only when phosphorylated at Tyr534
Form/Format
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1 mg/ml (lot specific)
Immunogen
A synthesized peptide derived from human Androgen Receptor (Phospho-Tyr534)
Immunogen Type
Peptide
Purification
Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Target Name
Androgen Receptor
Target Species
Human
Modification
Phospho-Tyr534
Preparation and Storage
Store at -20 degree C
Other Notes
Small volumes of anti-AR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-AR antibody
Applications Tested/Suitable for anti-AR antibody
Western Blot (WB)
Application Notes for anti-AR antibody
Western Blot: 1:1000

Western Blot (WB) of anti-AR antibody
Western blot analysis Androgen Receptor (Phospho-Tyr534) using UV treated COS7 whole cell lysates
anti-AR antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for AR. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
NCBI Official Full Name
androgen receptor isoform 1
NCBI Official Synonym Full Names
androgen receptor
NCBI Official Symbol
NCBI Official Synonym Symbols
KD; AIS; AR8; TFM; DHTR; SBMA; HYSP1; NR3C4; SMAX1; HUMARA
  [Similar Products]
NCBI Protein Information
androgen receptor
UniProt Protein Name
Androgen receptor
UniProt Synonym Protein Names
Dihydrotestosterone receptor; Nuclear receptor subfamily 3 group C member 4
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
DHTR; NR3C4  [Similar Products]
UniProt Entry Name
ANDR_HUMAN
NCBI Summary for AR
The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract from the normal 9-34 repeats to the pathogenic 38-62 repeats causes spinal bulbar muscular atrophy (SBMA, also known as Kennedy's disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2017]
UniProt Comments for AR
AR: a nuclear hormone receptor and transcription factor. Regulates gene expression and affects cellular proliferation and differentiation in target tissues. Two splice-variant isoforms have been described.

Protein type: DNA-binding; Nuclear receptor; Transcription factor

Chromosomal Location of Human Ortholog: Xq12

Cellular Component: cytoplasm; cytosol; nuclear chromatin; nucleoplasm; nucleus; protein complex

Molecular Function: androgen binding; androgen receptor activity; ATPase binding; beta-catenin binding; chromatin binding; enzyme binding; ligand-dependent nuclear receptor activity; protein binding; receptor binding; transcription factor activity; transcription factor binding

Biological Process: activation of NF-kappaB transcription factor; androgen receptor signaling pathway; cell-cell signaling; intracellular receptor-mediated signaling pathway; negative regulation of cell proliferation; negative regulation of integrin biosynthetic process; positive regulation of cell differentiation; positive regulation of cell proliferation; positive regulation of integrin biosynthetic process; positive regulation of phosphorylation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase III promoter; positive regulation of transcription, DNA-dependent; protein oligomerization; signal transduction; transcription initiation from RNA polymerase II promoter; transcription, DNA-dependent; transport

Disease: Androgen Insensitivity Syndrome; Androgen Insensitivity, Partial; Hypospadias 1, X-linked; Prostate Cancer; Spinal And Bulbar Muscular Atrophy, X-linked 1
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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