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anti-Bim antibody :: Rabbit Bim Polycolonal Antibody

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Catalog # MBS9416667
Unit / Price
  0.05 mL  /  $200 +1 FREE 8GB USB
  0.1 mL  /  $255 +1 FREE 8GB USB
Western Blot (WB)
Product Name

Bim, Polycolonal Antibody

Popular Item
Also Known As

Bim (Phospho-Thr56/116) Antibody

Product Synonym Names
BCL2L11; BIM-alpha6; BIM-beta7; Bcl-2-like protein 11; BIM-beta6; BimL; BimS; Bcl-2 interacting protein Bim; BimEL; BAM; Bcl2-L-11; BIM; BOD
Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
108
OMIM
AF032457 mRNA
3D Structure
ModBase 3D Structure for O43521
Clonality
Polycolonal
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Specificity
Bim (Phospho-Thr56/116) Antibody detects endogenous levels of Bim only when phosphorylated at Thr56/116
Form/Format
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1 mg/ml (lot specific)
Purification
Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi non-phosphopeptide
Immunogen
A synthesized peptide derived from human Bim (Phospho-Thr56/116)
Immunogen Type
Peptide
Target Species
human
Modification
Phospho-Thr56/116
Preparation and Storage
Store at -20 degree C
Other Notes
Small volumes of anti-Bim antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-Bim antibody
Rabbit Polyclonal Antibody
Product Categories/Family for anti-Bim antibody
Applications Tested/Suitable for anti-Bim antibody
Western Blot (WB)
Application Notes for anti-Bim antibody
Western Blot: 1:1000

Western Blot (WB) of anti-Bim antibody
Western blot analysis Bim (Phospho-Thr56/116) using EGF treated 293 whole cell lysates
anti-Bim antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for Bim. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
25kd, 22kd
NCBI Official Full Name
bcl-2-like protein 11 isoform 11
NCBI Official Synonym Full Names
BCL2 like 11
NCBI Official Symbol
BCL2L11  [Similar Products]
NCBI Official Synonym Symbols
BAM; BIM; BOD
  [Similar Products]
NCBI Protein Information
bcl-2-like protein 11
UniProt Protein Name
Bcl-2-like protein 11
UniProt Synonym Protein Names
Bcl2-interacting mediator of cell death
UniProt Gene Name
BCL2L11  [Similar Products]
UniProt Synonym Gene Names
BIM; Bcl2-L-11  [Similar Products]
UniProt Entry Name
B2L11_HUMAN
NCBI Summary for Bim
The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants of this gene have been identified. [provided by RefSeq, Jun 2013]
UniProt Comments for Bim
BIM: a pro-apoptotic member of the BCL-2 protein family. Interacts with other members of the BCL-2 protein family, including BCL2, BCL2L1/BCL-X(L), and MCL1, and act as an apoptotic activator. Its expression can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role in neuronal and lymphocyte apoptosis. Transgenic studies in the mouse suggested that this protein functions as an essential initiator of the apoptosis in thymocyte-negative selection. Nineteen alternatively spliced transcript variants of this gene have been reported.

Protein type: Apoptosis

Chromosomal Location of Human Ortholog: 2q13

Cellular Component: cytosol; mitochondrial outer membrane; mitochondrion

Molecular Function: protein binding

Biological Process: apoptosis; DNA damage response, signal transduction resulting in induction of apoptosis; meiosis I; positive regulation of apoptosis; positive regulation of protein homooligomerization; protein insertion into mitochondrial membrane during induction of apoptosis
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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