NP_004812.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
23,627 Da
NCBI Official Full Name
heart- and neural crest derivatives-expressed protein 1
NCBI Official Synonym Full Names
heart and neural crest derivatives expressed 1
NCBI Protein Information
heart- and neural crest derivatives-expressed protein 1
UniProt Protein Name
Heart- and neural crest derivatives-expressed protein 1
UniProt Synonym Protein Names
Class A basic helix-loop-helix protein 27; bHLHa27; Extraembryonic tissues, heart, autonomic nervous system and neural crest derivatives-expressed protein 1; eHAND
UniProt Synonym Gene Names
UniProt Entry Name
HAND1_HUMAN
NCBI Summary for HAND1
The protein encoded by this gene belongs to the basic helix-loop-helix family of transcription factors. This gene product is one of two closely related family members, the HAND proteins, which are asymmetrically expressed in the developing ventricular chambers and play an essential role in cardiac morphogenesis. Working in a complementary fashion, they function in the formation of the right ventricle and aortic arch arteries, implicating them as mediators of congenital heart disease. In addition, it has been suggested that this transcription factor may be required for early trophoblast differentiation. [provided by RefSeq, Jul 2008]
UniProt Comments for HAND1
HAND1: Transcription factor that plays an essential role in both trophoblast-giant cells differentiation and in cardiac morphogenesis. In the adult, could be required for ongoing expression of cardiac-specific genes. Binds the DNA sequence 5'- NRTCTG-3' (non-canonical E-box).
Protein type: Cell development/differentiation; DNA-binding; Nucleolus; Transcription factor
Chromosomal Location of Human Ortholog: 5q33
Cellular Component: cytoplasm; nucleus
Molecular Function: bHLH transcription factor binding; identical protein binding; protein binding; transcription coactivator activity; transcription corepressor activity; transcription factor binding
Biological Process: angiogenesis; blastocyst development; embryonic heart tube development; heart development; heart looping; negative regulation of transcription factor activity; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; transcription from RNA polymerase II promoter; trophectodermal cell differentiation; ventricular cardiac muscle morphogenesis
Research Articles on HAND1
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Products associated with anti-HAND1 antibody
Pathways associated with anti-HAND1 antibody
Diseases associated with anti-HAND1 antibody
Organs/Tissues associated with anti-HAND1 antibody
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