NP_005105.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
heparan sulfate glucosamine 3-O-sulfotransferase 1
NCBI Official Synonym Full Names
heparan sulfate (glucosamine) 3-O-sulfotransferase 1
NCBI Official Synonym Symbols
NCBI Protein Information
heparan sulfate glucosamine 3-O-sulfotransferase 1; 3-OST-1; h3-OST-1; heparan sulfate 3-O-sulfotransferase 1; heparin-glucosamine 3-O-sulfotransferase; heparan sulfate D-glucosaminyl 3-O-sulfotransferase 1
UniProt Protein Name
Heparan sulfate glucosamine 3-O-sulfotransferase 1
UniProt Synonym Protein Names
Heparan sulfate D-glucosaminyl 3-O-sulfotransferase 1; 3-OST-1; Heparan sulfate 3-O-sulfotransferase 1; h3-OST-1
UniProt Synonym Gene Names
3OST; 3OST1; 3-OST-1; Heparan sulfate 3-O-sulfotransferase 1; h3-OST-1 [Similar Products]
UniProt Entry Name
HS3S1_HUMAN
NCBI Summary for HS3ST1
Heparan sulfate biosynthetic enzymes are key components in generating a myriad of distinct heparan sulfate fine structures that carry out multiple biologic activities. The enzyme encoded by this gene is a member of the heparan sulfate biosynthetic enzyme family. It possesses both heparan sulfate glucosaminyl 3-O-sulfotransferase activity, anticoagulant heparan sulfate conversion activity, and is a rate limiting enzyme for synthesis of anticoagulant heparan. This enzyme is an intraluminal Golgi resident protein. [provided by RefSeq, Jul 2008]
UniProt Comments for HS3ST1
HS3ST1: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to position 3 of glucosamine residues in heparan. Catalyzes the rate limiting step in the biosynthesis of heparan sulfate (HSact). This modification is a crucial step in the biosynthesis of anticoagulant heparan sulfate as it completes the structure of the antithrombin pentasaccharide binding site. Belongs to the sulfotransferase 1 family.
Protein type: Glycan Metabolism - heparan sulfate biosynthesis; EC 2.8.2.23; Transferase
Chromosomal Location of Human Ortholog: 4p16
Cellular Component: Golgi lumen; integral to membrane
Molecular Function: sulfotransferase activity; heparin-glucosamine 3-O-sulfotransferase activity
Biological Process: glycosaminoglycan biosynthetic process; glycosaminoglycan metabolic process; carbohydrate metabolic process; pathogenesis
Research Articles on HS3ST1
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Products associated with HS3ST1 elisa kit
Pathways associated with HS3ST1 elisa kit
Diseases associated with HS3ST1 elisa kit
Organs/Tissues associated with HS3ST1 elisa kit
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