NP_002713.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
10,445 Da
NCBI Official Full Name
pancreatic prohormone preproprotein
NCBI Official Synonym Full Names
pancreatic polypeptide
NCBI Official Synonym Symbols
NCBI Protein Information
pancreatic prohormone; PP; pancreatic polypeptide Y; prepro-PP (prepropancreatic polypeptide)
UniProt Protein Name
Pancreatic prohormone
UniProt Synonym Protein Names
Pancreatic polypeptide; PP; INN: ObinepitideCleaved into the following 2 chains:Pancreatic hormone; PH; Pancreatic icosapeptide; PI
UniProt Synonym Gene Names
UniProt Entry Name
PAHO_HUMAN
NCBI Summary for PP
This gene belongs to the NPY family and it encodes a protein that is synthesized as a 95 aa polypeptide precursor in the pancreatic islets of Langerhans. It is cleaved into two peptide products; the active hormone of 36 aa and an icosapeptide of unknown function. The hormone acts as a regulator of pancreatic and gastrointestinal functions and may be important in the regulation of food intake. Plasma level of this hormone has been shown to be reduced in conditions associated with increased food intake and elevated in anorexia nervosa. In addition, infusion of this hormone in obese rodents has shown to decrease weight gain. [provided by RefSeq, Jul 2008]
UniProt Comments for PP
PPY: Pancreatic hormone is synthesized in pancreatic islets of Langerhans and acts as a regulator of pancreatic and gastrointestinal functions. Belongs to the NPY family.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 17q21
Cellular Component: extracellular space; extracellular region
Molecular Function: neuropeptide hormone activity; G-protein-coupled receptor binding; hormone activity; receptor binding
Biological Process: cell-cell signaling; neuropeptide signaling pathway; digestion; regulation of appetite; protein secretion; feeding behavior
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Products associated with PP elisa kit
Pathways associated with PP elisa kit
Diseases associated with PP elisa kit
Organs/Tissues associated with PP elisa kit
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