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PPARgC1a recombinant protein :: Peroxisome Proliferator Activated Receptor Gamma Coactivator 1 Alpha (PPARgC1a) Recombinant Protein

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Catalog # MBS2009392 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
Unit / Price
  0.01 mg  /  $150 +1 FREE 8GB USB
  0.05 mg  /  $285 +1 FREE 8GB USB
  0.1 mg  /  $445 +1 FREE 8GB USB
  0.2 mg  /  $550 +1 FREE 8GB USB
  0.5 mg  /  $1,060 +1 FREE 8GB USB
  1 mg  /  $1,580 +1 FREE 8GB USB
Product Name

Peroxisome Proliferator Activated Receptor Gamma Coactivator 1 Alpha (PPARgC1a), Recombinant Protein

Popular Item
Also Known As

Recombinant Peroxisome Proliferator Activated Receptor Gamma Coactivator 1 Alpha (PPARgC1a)

Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 14; NC_005113.3 (63182479..63286252). Location: 14q11
3D Structure
ModBase 3D Structure for Q9QYK2
Host
E.coli
Species Reactivity
Rat
Purity/Purification
>92%
Form/Format
PBS, pH7.4, containing 1mM DTT, 5% trehalose, 0.01% sarcosyl and Proclin300.
Concentration
200ug/mL (lot specific)
Source
Prokaryotic expression
Residues
Ser588~Ser773
Tags
N-terminal His-Tag
Tissue Specificity
Heart
Subcellular Location
Nucleus
Traits
Freeze-dried powder
Predicted isoelectric point
8.6
Predicted Molecular Mass
23.8kDa
Accurate Molecular Mass
22kDa as determined by SDS-PAGE reducing conditions
Usage
Reconstitute in PBS (pH7.4) to a concentration of 0.1-1.0 mg/mL. Do not vortex
Preparation and Storage
Storage: Avoid repeated freeze/thaw cycles.
Store at 2-8 degree C for one month.
Aliquot and store at -80 degree C for 12 months.
Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Other Notes
Small volumes of PPARgC1a recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for PPARgC1a recombinant protein
SDS-PAGE, WB, ELISA, IP, CoIP, Purification, Amine Reactive Labeling.

(May be suitable for use in other assays to be determined by the end user.)

Sequence Information of PPARgC1a recombinant protein
PPARgC1a recombinant protein Sequence Information image
NCBI/Uniprot data below describe general gene information for PPARgC1a. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Related Accession #
NCBI Official Full Name
peroxisome proliferator-activated receptor gamma coactivator 1-alpha
NCBI Official Synonym Full Names
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
NCBI Official Symbol
Ppargc1a  [Similar Products]
NCBI Official Synonym Symbols
Ppargc1
  [Similar Products]
NCBI Protein Information
peroxisome proliferator-activated receptor gamma coactivator 1-alpha; PGC-1alpha; PGC-1-alpha; PPARGC-1-alpha; PPAR-gamma coactivator 1-alpha; peroxisome proliferative activated receptor gamma coactivator 1; peroxisome proliferative activated receptor, gamma, coactivator 1 alpha
UniProt Protein Name
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha
UniProt Gene Name
Ppargc1a  [Similar Products]
UniProt Synonym Gene Names
Pgc1; Pgc1a; Ppargc1; PGC-1-alpha; PPAR-gamma coactivator 1-alpha  [Similar Products]
UniProt Entry Name
PRGC1_RAT
NCBI Summary for PPARgC1a
nuclear receptor coactivator; may mediate glucose homeostasis, and lipid homeostasis [RGD, Feb 2006]
UniProt Comments for PPARgC1a
PGC-1 alpha: a transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor genes. Interacts with, and regulates the activities of, cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs). Regulates many genes involved in energy metabolism. Provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determination. Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism. May be involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the development of obesity. Its transcription is repressed by ZNF746 which binds to 'insulin response sequences' in its promoter. Heavily acetylated by GCN5 and biologically inactive under conditions of high nutrients. Deacetylated by SIRT1 in low nutrients/high NAD conditions.

Protein type: Nuclear receptor co-regulator; Transcription, coactivator/corepressor
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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