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PPM1B cdna clone

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Catalog # MBS1276670
Unit / Price
  0.01 mg Plasmid + 0.2 mL Glycerol-Stock  /  $165 +1 FREE 8GB USB
PPM1B cdna clone
Product Name

PPM1B, cDNA Clone

Popular Item
Also Known As

PPM1B cDNA Clone

Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Length
579
Sequence
atgagtattg tactagtttg cttttcaaat gctcccaagg tctcagatga agcggtgaaa aaagattcag agttggataa gcacttggaa tcacgggttg aagagattat ggagaagtct ggcgaggaag gaatgcctga tcttgcccat gtcatgcgca tcttgtctgc agaaaatatc ccaaatttgc ctcctggggg aggtcttgct ggcaagcgta atgttattga agctgtttat agtagactga atccacatag agaaagtgat ggggcctccg atgaagcaga ggaaagtgga tcacagggaa aattggtgga agctctcagg caaatgagaa ttaatcatag gggaaactac cgacaacttc tggaggagat gctgactagt tacaggctag ctaaagtaga gggagaagaa agccctgctg aaccagctgc cacagctact tcttcgaaca gtgatgctgg aaacccagtg acaatgcagg aaagccatac tgaatcagaa agtggtcttg ctgaattaga cagctctaat gaagatgcag ggacaaagat gagtggtgaa aaaatatga
OMIM
603770
Vector
pENTR223.1
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of PPM1B cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for PPM1B. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
36,313 Da
NCBI Official Full Name
Homo sapiens protein phosphatase 1B (formerly 2C), magnesium-dependent, beta isoform, mRNA
NCBI Official Synonym Full Names
protein phosphatase, Mg2+/Mn2+ dependent 1B
NCBI Official Symbol
PPM1B  [Similar Products]
NCBI Official Synonym Symbols
PP2CB; PP2CBETA; PP2C-beta; PPC2BETAX; PP2C-beta-X
  [Similar Products]
NCBI Protein Information
protein phosphatase 1B
UniProt Protein Name
Protein phosphatase 1B
UniProt Synonym Protein Names
Protein phosphatase 2C isoform beta; PP2C-beta
Protein Family
UniProt Gene Name
PPM1B  [Similar Products]
UniProt Synonym Gene Names
PP2CB; PP2C-beta  [Similar Products]
UniProt Entry Name
PPM1B_HUMAN
NCBI Summary for PPM1B
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase has been shown to dephosphorylate cyclin-dependent kinases (CDKs), and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to cause cell-growth arrest or cell death. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional transcript variants have been described, but currently do not represent full-length sequences. [provided by RefSeq, Jul 2008]
UniProt Comments for PPM1B
PPM1B: ubiquitous cytosolic Ser/Thr protein phosphatase, catalytic subunit. The holoenzyme consists of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B'/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules.

Protein type: Protein phosphatase, Ser/Thr (non-receptor); EC 3.1.3.16; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 2p21

Cellular Component: cytosol; membrane

Molecular Function: protein binding; protein serine/threonine phosphatase activity

Biological Process: N-terminal protein myristoylation; negative regulation of defense response to virus; negative regulation of I-kappaB kinase/NF-kappaB cascade; negative regulation of interferon-beta production; negative regulation of NF-kappaB import into nucleus; protein amino acid dephosphorylation
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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