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Prf1 recombinant protein :: Perforin-1 Recombinant Protein

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Catalog # MBS950325
Unit / Price
  0.01 mg (Yeast)  /  $230 +1 FREE 8GB USB
  0.01 mg (E-Coli)  /  $235 +1 FREE 8GB USB
  0.05 mg (Yeast)  /  $305 +1 FREE 8GB USB
  0.05 mg (E-Coli)  /  $320 +1 FREE 8GB USB
  0.1 mg (Yeast)  /  $510 +1 FREE 8GB USB
  0.1 mg (E-Coli)  /  $535 +1 FREE 8GB USB
  0.2 mg (Yeast)  /  $815 +1 FREE 8GB USB
  0.2 mg (E-Coli)  /  $855 +1 FREE 8GB USB
  0.5 mg (E-Coli)  /  $1,125 +1 FREE 8GB USB
  0.5 mg (Yeast)  /  $1,345 +1 FREE 8GB USB
  1 mg (E-Coli)  /  $1,725 +2 FREE 8GB USB
  1 mg (Yeast)  /  $2,065 +2 FREE 8GB USB
SDS-PAGE
Product Name

Perforin-1 (Prf1), Recombinant Protein

Popular Item
Full Product Name

Recombinant Mouse Perforin-1

Product Synonym Names
P1; Cytolysin; Lymphocyte pore-forming protein
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
MBS950325 COA
Sequence Positions
638-767. partial protein;
Sequence
SMVLGSGSGV FKCGIAVAPV SRWEYYDSVY TERYMGLPTP EDNLDHYRNS TVMSRAENFK QVEYLLIHGT ADDNVHFQQS AQISKALVDA GVDFQAMWYT DEDHGIASST AHQHIYSHMS HFLQQCFSLR
3D Structure
ModBase 3D Structure for P10820
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
Greater than 90% as determined by SDS-PAGE. (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Species
Mus musculus (Mouse)
Preparation and Storage
Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of Prf1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
Prf1 recombinant protein
Plays a key role in secretory granule-dependent cell death, and in defense against virus-infected or neoplastic cells. Can insert into the membrane of target cells in its calcium-bound form, oligomerize and form large pores. Promotes cytolysis and apoptosis of target cells by facilitating the uptake of cytotoxic granzymes.
Product Categories/Family for Prf1 recombinant protein

Prf1 recombinant protein SDS-PAGE image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
NCBI/Uniprot data below describe general gene information for Prf1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Related Accession #
Molecular Weight
63.98kD
NCBI Official Full Name
perforin-1
NCBI Official Synonym Full Names
perforin 1 (pore forming protein)
NCBI Official Symbol
NCBI Official Synonym Symbols
Pfn; Pfp; Prf-1
  [Similar Products]
NCBI Protein Information
perforin-1
UniProt Protein Name
Perforin-1
UniProt Synonym Protein Names
Cytolysin; Lymphocyte pore-forming protein
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
Pfp; P1  [Similar Products]
UniProt Entry Name
PERF_MOUSE
UniProt Comments for Prf1
PRF1: Plays a key role in secretory granule-dependent cell death, and in defense against virus-infected or neoplastic cells. Plays an important role in killing other cells that are recognized as non-self by the immune system, e.g. in transplant rejection or some forms of autoimmune disease. Can insert into the membrane of target cells in its calcium-bound form, oligomerize and form large pores. Promotes cytolysis and apoptosis of target cells by facilitating the uptake of cytotoxic granzymes. Monomer, as sobluble protein. Homooligomer. Oligomerization is required for pore formation. Repressed by contact with target cells. Belongs to the complement C6/C7/C8/C9 family.

Protein type: Membrane protein, multi-pass

Cellular Component: cytoplasmic membrane-bound vesicle; cytoplasmic vesicle; endosome; extracellular region; extracellular space; integral to membrane; membrane; plasma membrane

Molecular Function: calcium ion binding; metal ion binding; wide pore channel activity

Biological Process: apoptosis; circadian rhythm; cytolysis; defense response to tumor cell; defense response to virus; formation of immunological synapse; immune response to tumor cell; protein homooligomerization; transmembrane transport
Product References and Citations for Prf1 recombinant protein
"The molecular basis for perforin oligomerization and transmembrane pore assembly." Baran K., Dunstone M., Chia J., Ciccone A., Browne K.A., Clarke C.J.P., Lukoyanova N., Saibil H., Whisstock J.C., Voskoboinik I., Trapani J.A. Immunity 30:684-695(2009)

Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Organs/Tissues associated with Prf1 recombinant protein
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