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Prkci recombinant protein :: Protein kinase C iota type (Prkci) Recombinant Protein

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Catalog # MBS1009498
Unit / Price
  0.05 mg (E-Coli)  /  $1,015 +1 FREE 8GB USB
  0.05 mg (Baculovirus)  /  $1,200 +1 FREE 8GB USB
  0.2 mg (E-Coli)  /  $1,370 +1 FREE 8GB USB
  0.05 mg (Mammalian-Cell)  /  $1,450 +1 FREE 8GB USB
  0.2 mg (Yeast)  /  $1,460 +1 FREE 8GB USB
  0.5 mg (E-Coli)  /  $1,515 +1 FREE 8GB USB
  0.1 mg (Baculovirus)  /  $1,525 +1 FREE 8GB USB
  0.5 mg (Yeast)  /  $1,650 +2 FREE 8GB USB
  1 mg (E-Coli)  /  $2,155 +2 FREE 8GB USB
  0.5 mg (Baculovirus)  /  $2,180 +2 FREE 8GB USB
  0.1 mg (Mammalian-Cell)  /  $2,185 +2 FREE 8GB USB
  1 mg (Yeast)  /  $2,495 +3 FREE 8GB USB
  1 mg (Baculovirus)  /  $2,860 +3 FREE 8GB USB
Prkci recombinant protein
Product Name

Protein kinase C iota type (Prkci), Recombinant Protein

Also Known As

Recombinant Rat Protein kinase C iota type (Prkci)

Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
2-596aa, Full Length of Mature Protein
Sequence Length
596
Sequence
PTQRDSSTMS HTVACGGGGD HSHQVRVKAY YRGDIMITHF EPSISFEGLC SEVRDMCSFD NEQPFTMKWI DEEGDPCTVS SQLELEEAFR LYELNKDSEL LIHVFPCVPE RPGMPCPGED KSIYRRGARR WRKLYCANGH TFQAKRFNRR AHCAICTDRI WGLGRQGYKC INCKLLVHKK CHKLVTIECG RHSLPPEPMM PMDQSSMHPD HTQTVIPYNP SSHESLDQVG EEKEAMNTRE SGKASSSLGL QDFDLLRVIG RGSYAKVLLV RLKKTDRIYA MKVVKKELVN DDEDIDWVQT EKHVFEQASN HPFLVGLHSC FQTESRLFFV IEYVNGGDLM FHMQRQRKLP EEHARFYSAE ISLALNYLHE RGIIYRDLKL DNVLLDSEGH IKLTDYGMCK EGLRPGDTTS TFCGTPNYIA PEILRGEDYG FSVDWWALGV LMFEMMAGRS PFDIVGSSDN PDQNTEDYLF QVILEKQIRI PRSLSVKAAS VLKSFLNKDP KERLGCHPQT GFADIQGHPF FRNVDWDMME QKQVVPPFKP NISGEFGLDN FDSQFTNEPV QLTPDDDDIV RKIDQSEFEG FEYINPLLMS AEECV
3D Structure
ModBase 3D Structure for F1M7Y5
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Species
Rat
Storage Buffer
Tris-based buffer, 50% glycerol
Tag Information
Tag type will be determined during the manufacturing process
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of Prkci recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for Prkci. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
68,276 Da
NCBI Official Full Name
protein kinase C iota type
NCBI Official Synonym Full Names
protein kinase C, iota
NCBI Official Symbol
Prkci  [Similar Products]
NCBI Official Synonym Symbols
NCBI Protein Information
protein kinase C iota type
UniProt Protein Name
Protein kinase C iota type
UniProt Synonym Protein Names
Atypical protein kinase C-lambda/iota; aPKC-lambda/iota; nPKC-iota
Protein Family
UniProt Gene Name
Prkci  [Similar Products]
UniProt Synonym Gene Names
Pkcl; aPKC-lambda/iota  [Similar Products]
NCBI Summary for Prkci
member of the atypical subgroup of PKCs that do not contain the calcium binding domain and possess only one cysteine-rich region; plays a critical role in controlling cell growth and cell survival; enhances Rab2-mediated vesicle budding [RGD, Feb 2006]
UniProt Comments for Prkci
Calcium- and diacylglycerol-independent serine/ threonine-protein kinase that plays a general protective role against apoptotic stimuli, is involved in NF-kappa-B activation, cell survival, differentiation and polarity, and contributes to the regulation of microtubule dynamics in the early secretory pathway. Is necessary for BCR-ABL oncogene-mediated resistance to apoptotic drug in leukemia cells, protecting leukemia cells against drug-induced apoptosis. In cultured neurons, prevents amyloid beta protein-induced apoptosis by interrupting cell death process at a very early step. In glioblastoma cells, may function downstream of phosphatidylinositol 3-kinase (PI3K) and PDPK1 in the promotion of cell survival by phosphorylating and inhibiting the pro-apoptotic factor BAD. Can form a protein complex in non-small cell lung cancer (NSCLC) cells with PARD6A and ECT2 and regulate ECT2 oncogenic activity by phosphorylation, which in turn promotes transformed growth and invasion. In response to nerve growth factor (NGF), acts downstream of SRC to phosphorylate and activate IRAK1, allowing the subsequent activation of NF-kappa-B and neuronal cell survival. Functions in the organization of the apical domain in epithelial cells by phosphorylating EZR. This step is crucial for activation and normal distribution of EZR at the early stages of intestinal epithelial cell differentiation. Forms a protein complex with LLGL1 and PARD6B independently of PARD3 to regulate epithelial cell polarity. Plays a role in microtubule dynamics in the early secretory pathway through interaction with RAB2A and GAPDH and recruitment to vesicular tubular clusters (VTCs). In human coronary artery endothelial cells (HCAEC), is activated by saturated fatty acids and mediates lipid-induced apoptosis. Downstream of PI3K is required for insulin-stimulated glucose transport. Activates RAB4A and promotes its association with KIF3A which is required for the insulin-induced SLC2A4/GLUT4 translocation in adipocytes. Is essential in early embryogenesis and development of differentiating photoreceptors by playing a role in the establishment of epithelial and neuronal polarity ().
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated withPrkci recombinant protein
 Reference Product  PubMed Publications
 Pard3 recombinant protein  >2 publications with Prkci and Pard3
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