PRKRA recombinant protein :: Interferon-inducible double stranded RNA-dependent protein kinase activator A (PRKRA) Recombinant Protein

Catalog #	MBS1422845
Unit / Price	0.01 mg (E-Coli) / $235 +1 FREE 8GB USB 0.05 mg (E-Coli) / $320 +1 FREE 8GB USB 0.1 mg (E-Coli) / $535 +1 FREE 8GB USB 0.2 mg (E-Coli) / $855 +1 FREE 8GB USB 0.5 mg (E-Coli) / $1,125 +1 FREE 8GB USB 1 mg (E-Coli) / $1,725 +2 FREE 8GB USB

Product Name

Interferon-inducible double stranded RNA-dependent protein kinase activator A (PRKRA), Recombinant Protein

Recombinant Bovine Interferon-inducible double stranded RNA-dependent protein kinase activator A (PRKRA)

Product Gene Name

PRKRA recombinant protein

[Similar Products]

Product Synonym Gene Name

PRKRA[Similar Products]

Research Use Only

For Research Use Only. Not for use in diagnostic procedures.

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MBS1422845 COA

COA PDF

Sequence Positions

1-313aa, Full Length

Sequence

MSQSRHRAAA PPMEREDSGT FSLGKMITAK PGKTPIQVLH EYGMKTKNIP VYECERSDVQ IHVPTFTFRV TVGDITCTGE GTSKKLAKHR AAEAAINILK ANASICFAVP DPLMPDPSKQ PKNQLNPIGS LQELAIHHGW RLPEYTLSQE GGPAHKREYT TICRLESFME TGKGASKKQA KRNAAEKFLA KFSNISPENH ISLTNMVGHS LGCTWHSLRN SPGEKINLLK RSLLSIPNTD YIQLLSEIAK EQGFNITYLD IEELSANGQY QCLAELSTSP ITVCHGSGIS CSSAQSDAAH NALQYLKIIA ERK

3D Structure

ModBase 3D Structure for Q2HJ92

Host

E Coli or Yeast or Baculovirus or Mammalian Cell

Purity/Purification

Greater than 85% as determined by SDS-PAGE. (lot specific)

Form/Format

Liquid containing glycerol

Tag Information

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterility

Sterile filter available upon request.

Endotoxin

Low endotoxin available upon request.

Species

Bos taurus (Bovine)

Storage Buffer

Tris-based buffer, 50% glycerol

Tag Information

Tag type will be determined during the manufacturing process

Preparation and Storage

Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

ISO Certification

Manufactured in an ISO 9001:2008 Certified Laboratory.

Other Notes

Small volumes of PRKRA recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

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Related Product Information for
PRKRA recombinant protein

Activates EIF2AK2
PKR in the absence of double-stranded RNA (dsRNA), leading to phosphorylation of EIF2S1
EFI2-alpha and inhibition of translation and induction of apoptosis. Required for siRNA production by DICER1 and for subsequent siRNA-mediated post-transcriptional gene silencing. Does not seem to be required for processing of pre-miRNA to miRNA by DICER1. Promotes UBC9-p53
TP53 association and sumoylation and phosphorylation of p53
TP53 at 'Lys-386' at 'Ser-392' respectively and enhances its activity in a EIF2AK2
PKR-dependent manner

Product Categories/Family for PRKRA recombinant protein

Epigenetics and Nuclear Signaling

SDS-Page of PRKRA recombinant protein

PRKRA recombinant protein SDS-Page image

(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)

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NCBI/Uniprot data below describe general gene information for PRKRA. It may not necessarily be applicable to this product.

NCBI GI #

114052769

NCBI GeneID

282875

NCBI Accession #

NP_001039335.1 [Other Products]

NCBI GenBank Nucleotide #

NM_001045870.1 [Other Products]

UniProt Primary Accession #

Q2HJ92 [Other Products]

UniProt Related Accession #

Q2HJ92[Other Products]

Molecular Weight

39.4 kDa

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NCBI Official Full Name

interferon-inducible double-stranded RNA-dependent protein kinase activator A

NCBI Official Synonym Full Names

protein activator of interferon induced protein kinase EIF2AK2

NCBI Official Symbol

PRKRA [Similar Products]

NCBI Official Synonym Symbols

PACT

[Similar Products]

NCBI Protein Information

interferon-inducible double-stranded RNA-dependent protein kinase activator A

UniProt Protein Name

Interferon-inducible double-stranded RNA-dependent protein kinase activator A

UniProt Synonym Protein Names

Protein activator of the interferon-induced protein kinase; Protein kinase, interferon-inducible double-stranded RNA-dependent activator

Protein Family

Interferon-inducible double-stranded RNA-dependent protein kinase activator

UniProt Gene Name

PRKRA [Similar Products]

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UniProt Comments for PRKRA

Activates EIF2AK2/PKR in the absence of double-stranded RNA (dsRNA), leading to phosphorylation of EIF2S1/EFI2-alpha and inhibition of translation and induction of apoptosis. Required for siRNA production by DICER1 and for subsequent siRNA-mediated post-transcriptional gene silencing. Does not seem to be required for processing of pre-miRNA to miRNA by DICER1. Promotes UBC9-p53/TP53 association and sumoylation and phosphorylation of p53/TP53 at 'Lys-386' at 'Ser-392' respectively and enhances its activity in a EIF2AK2/PKR-dependent manner ().

Research Articles on PRKRA

1. Tumour necrosis factor alpha up-regulates protein kinase R (PKR)-activating protein (PACT, PRKRA) and increases phosphorylation of PKR and eukaryotic initiation factor 2-alpha in articular chondrocytes.

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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

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Products associated withPRKRA recombinant protein

Reference Product	PubMed Publications
DICER1 recombinant protein	>8 publications with PRKRA and DICER1
EIF2C2 recombinant protein	>6 publications with PRKRA and EIF2C2
TARBP2 recombinant protein	>4 publications with PRKRA and TARBP2
ATP7B recombinant protein	>1 publications with PRKRA and ATP7B
PPP1CA recombinant protein	>1 publications with PRKRA and PPP1CA
RNASEN recombinant protein	>1 publications with PRKRA and RNASEN

Pathways associated with PRKRA recombinant protein

Products by Pathway	Pathway Diagram
Gene Expression Pathway antibodies	Gene Expression Pathway Diagram
MicroRNA (miRNA) Biogenesis Pathway antibodies	MicroRNA (miRNA) Biogenesis Pathway Diagram
Regulatory RNA Pathways antibodies	Regulatory RNA Pathways Diagram
Small Interfering RNA (siRNA) Biogenesis Pathway antibodies	Small Interfering RNA (siRNA) Biogenesis Pathway Diagram

Diseases associated with PRKRA recombinant protein

Disease Name	Pubmed Publications
Nervous System Diseases Antibodies	>12 publications with PRKRA and Nervous System Diseases
Dystonia Antibodies	>11 publications with PRKRA and Dystonia
Brain Diseases Antibodies	>8 publications with PRKRA and Brain Diseases
Necrosis Antibodies	>1 publications with PRKRA and Necrosis
Seizures Antibodies	>1 publications with PRKRA and Seizures
Precancerous Conditions Antibodies	>1 publications with PRKRA and Precancerous Conditions
Hyperplasia Antibodies	>1 publications with PRKRA and Hyperplasia
Disease Models, Animal Antibodies	>1 publications with PRKRA and Disease Models, Animal

Organs/Tissues associated with PRKRA recombinant protein

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>8 publications with PRKRA and Brain
Muscle Antibodies	>2 publications with PRKRA and Muscle
Intestine Antibodies	>1 publications with PRKRA and Intestine