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PRL-3 recombinant protein

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Catalog # MBS203399
Unit / Price
  0.1 mg  /  $255 +1 FREE 8GB USB
  0.5 mg  /  $535 +1 FREE 8GB USB
SDS-Page
Product Name

PRL-3, Recombinant Protein

Also Known As

PRL-3, 1-173aa, Human, His tag, E Coli

Product Synonym Names
Protein tyrosine phosphatase type IVA 3; PTP4A3; PRL3; Protein tyrosine phosphatase type IVA 3 Potentially prenylated protein tyrosine phosphatase; PRL 3; PRL R; PRLR; Protein tyrosine phosphatase 4a3; PTP 4A3; Protein Tyrosine Phosphatase Type IVA Member 3
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Length
173
Sequence
MGSSHHHHHH SSGLVPRGSH MARMNRPAPV EVSYKHMRFL ITHNPTNATL STFIEDLKKY GATTVVRVCE VTYDKTPLEK DGITVVDWPF DDGAPPPGKV VEDWLSLVKA KFCEAPGSCV AVHCVAGLGR APVLVALALI ESGMKYEDAI QFIRQKRRGA INSKQLTYLE KYRPKQRLRF KDPHTHKTRC CVM
OMIM
AF041434 mRNA
3D Structure
ModBase 3D Structure for O75365
Host
E Coli
Purity/Purification
> 95% by SDS-PAGE
Form/Format
Liquid. In 20 mM Tris-HCl Buffer (pH 8.0) containing 2 mM EDTA, 1 mM DTT, 10% glycerol
Concentration
1 mg/ml (determined by Bradford assay) (lot specific)
Antigen Species
Human
Tag Information
His-tag
Endotoxin Level
< 1.0 EU per 1 microgram of protein (determined by LAL method)
Preparation and Storage
Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
Other Notes
Small volumes of PRL-3 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
PRL-3 recombinant protein
Protein tyrosine phosphatase type IVA 3 (PRL-3), as known as PTP4A3, belongs to a small class of prenylated protein tyrosine phosphatases (PTPs) that remove phosphate modifications from tyrosine residues on proteins. This protein enhances cell proliferation, cell motility and invasive activity. High levels of PRL-3 expression are associated with tumorigenesis and metastasis, thus it is overexpressed in metastatic colorectal, ovarian, liver and skin cancers. Recombinant human PRL-3, fused to His-tag at N-terminus, was expressed in E Coli and purified by using conventional chromatography.
Product Categories/Family for PRL-3 recombinant protein
Applications Tested/Suitable for PRL-3 recombinant protein
SDS-PAGE

NCBI/Uniprot data below describe general gene information for PRL-3. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
21.6 kDa (193aa), confirmed by MALDI-TOF.
NCBI Official Full Name
protein tyrosine phosphatase type IVA 3 isoform 1
NCBI Official Synonym Full Names
protein tyrosine phosphatase type IVA, member 3
NCBI Official Symbol
PTP4A3  [Similar Products]
NCBI Official Synonym Symbols
PRL3; PRL-3; PRL-R
  [Similar Products]
NCBI Protein Information
protein tyrosine phosphatase type IVA 3
UniProt Protein Name
Protein tyrosine phosphatase type IVA 3
UniProt Synonym Protein Names
PRL-R; Protein-tyrosine phosphatase 4a3; Protein-tyrosine phosphatase of regenerating liver 3; PRL-3
UniProt Gene Name
PTP4A3  [Similar Products]
UniProt Synonym Gene Names
PRL3; PRL-3  [Similar Products]
NCBI Summary for PRL-3
This gene encodes a member of the protein-tyrosine phosphatase family. Protein tyrosine phosphatases are cell signaling molecules that play regulatory roles in a variety of cellular processes. Studies of this class of protein tyrosine phosphatase in mice demonstrates that they are prenylated in vivo, suggesting their association with cell plasma membrane. The encoded protein may enhance cell proliferation, and overexpression of this gene has been implicated in tumor metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
UniProt Comments for PRL-3
Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. May be involved in the progression of cardiac hypertrophy by inhibiting intracellular calcium mobilization in response to angiotensin II.
Product References and Citations for PRL-3 recombinant protein
Ooki A., et al. (2009). Oncol Rep. 21 (6):1467-75; Wang Z., et al. (2009). Ann Surg Oncol. 16 (1):208-19.;

Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Pathways associated with PRL-3 recombinant protein
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