View our list of available Coronavirus (COVID-19, SARS-CoV-2, 2019-nCOV) antibodies, recombinant proteins, ELISA Kits... Options Full Datasheet Printer Friendly Datasheet Prepare for Printing Full Datasheet Printer Friendly Datasheet Prepare for Printing Have Questions? Ask Us! Add To Compare List BMP-2 active protein :: Bone Morphogenetic Protein-2 Active Protein Catalog # MBS506374 Unit / Price DISCONTINUEDClick here to view our similar product(s) OR click here to contact our technical support team for suitable replacement. Previous Next Product Name Product Info Accession #s Product Desc Diseases/Tissues/Pathways Applications References Product Name Bone Morphogenetic Protein-2 (BMP-2), Active Protein Popular Item Full Product Name Human/Mouse/Rat Bone Morphogenetic Protein-2 Product Synonym Names BMP-2A Product Gene Name BMP-2 active protein[Similar Products] Research Use Only For Research Use Only. Not for use in diagnostic procedures. TOP Sequence Positions 115-230 Sequence MQAKHKQRKR LKSSCKRHPL YVDFSDVGWN DWIVAPPGYH AFYCHGECPF PLADHLNSTN HAIVQTLVNS VNSKIPKACC VPTELSAISM LYLDENEKVV LKNYQDMVVE GCGCR OMIM 112261 3D Structure ModBase 3D Structure for P12643 Host E Coli Purity/Purification >=95% Form/Format Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 0.1% Trifluoroacetic Acid (TFA) Species Human/Mouse/Rat Endotoxin <=1.00 EUs/ug; Kinetic LAL (50% confidence) Biological Activity ED50 <=250 ng/mL (>=4 x 10^3 units/mg); Alkaline phosphatase activity induced in ATDC-5 Cells Monomer/Dimer Dimer Tag None Reconstitution Sterile water at 0.1 mg/mL Preparation and Storage 12 months from date of receipt when stored at -20 degree C to-80 degree C as supplied. 1 month when stored at 4 degree C after reconstituting as directed. 3 months when stored at -20 degree C to -80 degree C after reconstituting as directed. Active Protein Note Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product. Other Notes Small volumes of BMP-2 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply. TOP Related Product Information for BMP-2 active protein Bone morphogenic protein 2 (BMP2) is a member of the bone morphogenetic protein (BMP) family and functions as a potent inducer of bone and cartilage development. BMP proteins are synthesized as large precursor molecules which are cleaved by proteolytic enzymes. Active BMP2 consists of forming a homodimer or a heterodimer with a related BMP, such as BMP7. BMP2 signals through type I and type II receptor tyrosine kinases in conjuction with SMAD proteins to directly promote osteoblast differentiation. BMP2 is also important during cardiac development and supports epicardial cell migration. GEL Data of BMP-2 active protein Biological Activity of BMP-2 active protein TOP NCBI/Uniprot data below describe general gene information for BMP-2. It may not necessarily be applicable to this product. NCBI GI # 115068 NCBI GeneID 650 NCBI Accession # P12643.1 [Other Products] UniProt Primary Accession # P12643 [Other Products] UniProt Related Accession # P12643[Other Products] Molecular Weight 13.0; 26.0 TOP NCBI Official Full Name Bone morphogenetic protein 2 NCBI Official Synonym Full Names bone morphogenetic protein 2 NCBI Official Symbol BMP2 [Similar Products] NCBI Official Synonym Symbols BDA2; BMP2A; SSFSC [Similar Products] NCBI Protein Information bone morphogenetic protein 2 UniProt Protein Name Bone morphogenetic protein 2 UniProt Synonym Protein Names Bone morphogenetic protein 2A; BMP-2A UniProt Gene Name BMP2 [Similar Products] UniProt Synonym Gene Names BMP2A; BMP-2; BMP-2A [Similar Products] UniProt Entry Name BMP2_HUMAN TOP NCBI Summary for BMP-2 This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which plays a role in bone and cartilage development. Duplication of a regulatory region downstream of this gene causes a form of brachydactyly characterized by a malformed index finger and second toe in human patients. [provided by RefSeq, Jul 2016] TOP UniProt Comments for BMP-2 Induces cartilage and bone formation (PubMed:3201241). Stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3-EIF2A- ATF4 pathway. BMP2 activation of EIF2AK3 stimulates phosphorylation of EIF2A which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. In addition stimulates TMEM119, which upregulates the expression of ATF4 (PubMed:24362451). Research Articles on BMP-2 1. Ubiquitin-specific protease USP34 controls osteogenic differentiation and bone formation by regulating BMP2 signaling. TOP Precautions All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines. Disclaimer While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information. TOP Products associated with BMP-2 active protein Reference Product PubMed Publications BMPR2 active protein >206 publications with BMP-2 and BMPR2 BMPR1A active protein >179 publications with BMP-2 and BMPR1A SMAD4 active protein >95 publications with BMP-2 and SMAD4 BMPR1B active protein >58 publications with BMP-2 and BMPR1B SMAD7 active protein >33 publications with BMP-2 and SMAD7 NOG active protein >11 publications with BMP-2 and NOG ACVR2B active protein >9 publications with BMP-2 and ACVR2B GREM2 active protein >8 publications with BMP-2 and GREM2 CHRD active protein >3 publications with BMP-2 and CHRD SOSTDC1 active protein >2 publications with BMP-2 and SOSTDC1 Pathways associated with BMP-2 active protein Products by Pathway Pathway Diagram Adipogenesis Pathway antibodies Adipogenesis Pathway Diagram BDNF Signaling Pathway antibodies BDNF Signaling Pathway Diagram BMP Signaling Pathway antibodies BMP Signaling Pathway Diagram BMP Signaling Pathway antibodies BMP Signaling Pathway Diagram BMP Signalling And Regulation Pathway antibodies BMP Signalling And Regulation Pathway Diagram Basal Cell Carcinoma Pathway antibodies Basal Cell Carcinoma Pathway Diagram Basal Cell Carcinoma Pathway antibodies Basal Cell Carcinoma Pathway Diagram Cytokine-cytokine Receptor Interaction Pathway antibodies Cytokine-cytokine Receptor Interaction Pathway Diagram Cytokine-cytokine Receptor Interaction Pathway antibodies Cytokine-cytokine Receptor Interaction Pathway Diagram Elastic Fibre Formation Pathway antibodies Elastic Fibre Formation Pathway Diagram Diseases associated with BMP-2 active protein Disease Name Pubmed Publications Bone Diseases Antibodies >567 publications with BMP-2 and Bone Diseases Necrosis Antibodies >112 publications with BMP-2 and Necrosis Inflammation Antibodies >93 publications with BMP-2 and Inflammation Pain Antibodies >46 publications with BMP-2 and Pain Hypertrophy Antibodies >45 publications with BMP-2 and Hypertrophy Hypertension Antibodies >44 publications with BMP-2 and Hypertension Fibrosis Antibodies >34 publications with BMP-2 and Fibrosis Kidney Diseases Antibodies >32 publications with BMP-2 and Kidney Diseases Breast Neoplasms Antibodies >32 publications with BMP-2 and Breast Neoplasms Atherosclerosis Antibodies >25 publications with BMP-2 and Atherosclerosis Organs/Tissues associated with BMP-2 active protein Organ/Tissue Name Pubmed Publications Bone Antibodies >4170 publications with BMP-2 and Bone Connective Tissue Antibodies >647 publications with BMP-2 and Connective Tissue Embryonic Tissue Antibodies >455 publications with BMP-2 and Embryonic Tissue Heart Antibodies >192 publications with BMP-2 and Heart Brain Antibodies >161 publications with BMP-2 and Brain Kidney Antibodies >94 publications with BMP-2 and Kidney Lung Antibodies >82 publications with BMP-2 and Lung Liver Antibodies >70 publications with BMP-2 and Liver Eye Antibodies >63 publications with BMP-2 and Eye Uterus Antibodies >29 publications with BMP-2 and Uterus TOP © 2006-24 MyBioSource.com. All rights reserved. Privacy Policy | Terms & Conditions Our Best Sellers ATPase (ATP2B2) Antibody Platelet basic protein (PPBP) Active Protein Transforming Growth Factor Alpha (TGFA) ELISA Kit Apolipoprotein A-I (APOA1) Antibody Pelitinib (EKB-569) Inhibitor Meprin A Beta (MEP1b) Antibody COT Antibody CADM2 Antibody ELISA Antibodies Secondary Antibodies Antigens Biochemicals cDNA Clones Kits Peptides Rec Proteins Protein Family Request a Quote Please fill out the form below and our representative will get back to you shortly. Catalog # MBS000000 Your E-mail (required) Ship to Country (required) United StatesAfghanistanAlbaniaAlgeriaAmerican SamoaAndorraAngolaAnguillaAntarcticaAntigua and BarbudaArgentinaArmeniaArubaAustraliaAustriaAzerbaijanBahamasBahrainBangladeshBarbadosBelarusBelgiumBelizeBeninBermudaBhutanBoliviaBosnia and HerzegowinaBotswanaBouvet IslandBrazilBritish Indian Ocean TerritoryBrunei DarussalamBulgariaBurkina FasoBurundiCambodiaCameroonCanadaCape VerdeCayman IslandsCentral African RepublicChadChileChinaChristmas IslandCocos (Keeling) IslandsColombiaComorosCongoCook IslandsCosta RicaCote DIvoireCroatiaCubaCyprusCzech RepublicDenmarkDjiboutiDominicaDominican RepublicEast TimorEcuadorEgyptEl SalvadorEquatorial GuineaEritreaEstoniaEthiopiaFalkland Islands (Malvinas)Faroe IslandsFijiFinlandFranceFrance MetropolitanFrench GuianaFrench PolynesiaFrench Southern TerritoriesGabonGambiaGeorgiaGermanyGhanaGibraltarGreeceGreenlandGrenadaGuadeloupeGuamGuatemalaGuineaGuinea-bissauGuyanaHaitiHeard and Mc Donald IslandsHondurasHong KongHungaryIcelandIndiaIndonesiaIran (Islamic Republic of)IraqIrelandIsraelItalyJamaicaJapanJordanKazakhstanKenyaKiribatiKorea Democratic People Republic ofKorea Republic ofKuwaitKyrgyzstanLao People Democratic RepublicLatviaLebanonLesothoLiberiaLibyan Arab JamahiriyaLiechtensteinLithuaniaLuxembourgMacauMacedonia The Former Yugoslav Republic ofMadagascarMalawiMalaysiaMaldivesMaliMaltaMarshall IslandsMartiniqueMauritaniaMauritiusMayotteMexicoMicronesia Federated States ofMoldova Republic ofMonacoMongoliaMontserratMoroccoMozambiqueMyanmarNamibiaNauruNepalNetherlandsNetherlands AntillesNew CaledoniaNew ZealandNicaraguaNigerNigeriaNiueNorfolk IslandNorthern Mariana IslandsNorwayOmanPakistanPalauPanamaPapua New GuineaParaguayPeruPhilippinesPitcairnPolandPortugalPuerto RicoQatarReunionRomaniaRussian FederationRwandaSaint Kitts and NevisSaint LuciaSaint Vincent and the GrenadinesSamoaSan MarinoSao Tome and PrincipeSaudi ArabiaSenegalSeychellesSierra LeoneSingaporeSlovakia (Slovak Republic)SloveniaSolomon IslandsSomaliaSouth AfricaSouth Georgia and the South Sandwich IslandsSpainSri LankaSt. HelenaSt. Pierre and MiquelonSudanSurinameSvalbard and Jan Mayen IslandsSwazilandSwedenSwitzerlandSyrian Arab RepublicTaiwanTajikistanTanzania United Republic ofThailandTogoTokelauTongaTrinidad and TobagoTunisiaTurkeyTurkmenistanTurks and Caicos IslandsTuvaluUgandaUkraineUnited Arab EmiratesUnited KingdomUnited StatesUnited States Minor Outlying IslandsUruguayUzbekistanVanuatuVatican City State (Holy See)VenezuelaViet NamVirgin Islands (British)Virgin Islands (U.S.)Wallis and Futuna IslandsWestern SaharaYemenYugoslaviaZaireZambiaZimbabwe Postal/Zip Code (required) Your Name Your Telephone Your Inquiries, Comments or Full Shipping Address (required) Contact Us Please fill out the form below and our representative will get back to you shortly. Inquiry for # MBS000000 Your Name Your Telephone Your E-mail (required) Your Inquiries or Comments